diff --git a/src/Avalonia.Base/Layout/Layoutable.cs b/src/Avalonia.Base/Layout/Layoutable.cs
index b237c10e63..73c9e1ba0f 100644
--- a/src/Avalonia.Base/Layout/Layoutable.cs
+++ b/src/Avalonia.Base/Layout/Layoutable.cs
@@ -74,37 +74,37 @@ namespace Avalonia.Layout
         /// Defines the <see cref="Width"/> property.
         /// </summary>
         public static readonly StyledProperty<double> WidthProperty =
-            AvaloniaProperty.Register<Layoutable, double>(nameof(Width), double.NaN);
+            AvaloniaProperty.Register<Layoutable, double>(nameof(Width), double.NaN, validate: ValidateDimension);
 
         /// <summary>
         /// Defines the <see cref="Height"/> property.
         /// </summary>
         public static readonly StyledProperty<double> HeightProperty =
-            AvaloniaProperty.Register<Layoutable, double>(nameof(Height), double.NaN);
+            AvaloniaProperty.Register<Layoutable, double>(nameof(Height), double.NaN, validate: ValidateDimension);
 
         /// <summary>
         /// Defines the <see cref="MinWidth"/> property.
         /// </summary>
         public static readonly StyledProperty<double> MinWidthProperty =
-            AvaloniaProperty.Register<Layoutable, double>(nameof(MinWidth));
+            AvaloniaProperty.Register<Layoutable, double>(nameof(MinWidth), validate: ValidateMinimumDimension);
 
         /// <summary>
         /// Defines the <see cref="MaxWidth"/> property.
         /// </summary>
         public static readonly StyledProperty<double> MaxWidthProperty =
-            AvaloniaProperty.Register<Layoutable, double>(nameof(MaxWidth), double.PositiveInfinity);
+            AvaloniaProperty.Register<Layoutable, double>(nameof(MaxWidth), double.PositiveInfinity, validate: ValidateMaximumDimension);
 
         /// <summary>
         /// Defines the <see cref="MinHeight"/> property.
         /// </summary>
         public static readonly StyledProperty<double> MinHeightProperty =
-            AvaloniaProperty.Register<Layoutable, double>(nameof(MinHeight));
+            AvaloniaProperty.Register<Layoutable, double>(nameof(MinHeight), validate: ValidateMinimumDimension);
 
         /// <summary>
         /// Defines the <see cref="MaxHeight"/> property.
         /// </summary>
         public static readonly StyledProperty<double> MaxHeightProperty =
-            AvaloniaProperty.Register<Layoutable, double>(nameof(MaxHeight), double.PositiveInfinity);
+            AvaloniaProperty.Register<Layoutable, double>(nameof(MaxHeight), double.PositiveInfinity, validate: ValidateMaximumDimension);
 
         /// <summary>
         /// Defines the <see cref="Margin"/> property.
@@ -153,6 +153,10 @@ namespace Avalonia.Layout
                 VerticalAlignmentProperty);
         }
 
+        private static bool ValidateDimension(double value) => double.IsNaN(value) || ValidateMinimumDimension(value);
+        private static bool ValidateMinimumDimension(double value) => !double.IsPositiveInfinity(value) && ValidateMaximumDimension(value);
+        private static bool ValidateMaximumDimension(double value) => value >= 0;
+
         /// <summary>
         /// Occurs when the element's effective viewport changes.
         /// </summary>
diff --git a/tests/Avalonia.Base.UnitTests/Layout/LayoutableTests.cs b/tests/Avalonia.Base.UnitTests/Layout/LayoutableTests.cs
index c4b0795022..ab1c036b72 100644
--- a/tests/Avalonia.Base.UnitTests/Layout/LayoutableTests.cs
+++ b/tests/Avalonia.Base.UnitTests/Layout/LayoutableTests.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Collections.Generic;
 using Avalonia.Controls;
 using Avalonia.Layout;
 using Avalonia.UnitTests;
@@ -387,6 +388,29 @@ namespace Avalonia.Base.UnitTests.Layout
             Assert.Equal(default, child.DesiredSize);
         }
 
+        [Fact]
+        public void Size_Properties_Reject_Invalid_Values()
+        {
+            var target = new Layoutable();
+
+            Assert.Multiple(() =>
+            {
+                SetShouldThrow([Layoutable.WidthProperty, Layoutable.HeightProperty], double.PositiveInfinity);
+                SetShouldThrow([Layoutable.WidthProperty, Layoutable.HeightProperty], -10);
+
+                SetShouldThrow([Layoutable.MinWidthProperty, Layoutable.MinHeightProperty], double.PositiveInfinity);
+                SetShouldThrow([Layoutable.MinWidthProperty, Layoutable.MinHeightProperty], -10);
+
+                SetShouldThrow([Layoutable.MaxWidthProperty, Layoutable.MaxHeightProperty], -10);
+
+                void SetShouldThrow(IEnumerable<StyledProperty<double>> properies, double value)
+                {
+                    foreach (var prop in properies)
+                        Assert.Throws<ArgumentException>(() => target.SetValue(prop, value));
+                }
+            });
+        }
+
         private class TestLayoutable : Layoutable
         {
             public Size ArrangeSize { get; private set; }