diff --git a/src/Avalonia.Controls.DataGrid/DataGridBoundColumn.cs b/src/Avalonia.Controls.DataGrid/DataGridBoundColumn.cs
index 8e82bf1a38..440a277a10 100644
--- a/src/Avalonia.Controls.DataGrid/DataGridBoundColumn.cs
+++ b/src/Avalonia.Controls.DataGrid/DataGridBoundColumn.cs
@@ -49,8 +49,13 @@ namespace Avalonia.Controls
                     {
                         if(_binding is Avalonia.Data.Binding binding)
                         {
+                            if (binding.Mode == BindingMode.OneWayToSource)
+                            {
+                                throw new InvalidOperationException("DataGridColumn doesn't support BindingMode.OneWayToSource");
+                            }
+
                             // Force the TwoWay binding mode if there is a Path present.  TwoWay binding requires a Path.
-                            if (!String.IsNullOrEmpty(binding.Path))
+                            if (!String.IsNullOrEmpty(binding.Path) && binding.Mode == BindingMode.Default)
                             {
                                 binding.Mode = BindingMode.TwoWay;
                             }