Try fixing the sporadic Bindings Exceptions.

src/Avalonia.Animation/Animator`1.cs

@@ -1,14 +1,12 @@
 using System;
 using System.Collections.Generic;
 using System.Linq;
-using System.Reactive.Disposables;
 using System.Reactive.Linq;
 using Avalonia.Animation.Utils;
 using Avalonia.Collections;
 using Avalonia.Data;
 using Avalonia.Reactive;
 
-
 namespace Avalonia.Animation
 {
     /// <summary>
@@ -41,8 +39,7 @@ namespace Avalonia.Animation
                 VerifyConvertKeyFrames();
 
             return match.DistinctUntilChanged()
-                        .ObserveOn(Avalonia.Threading.AvaloniaScheduler.Instance)
-                        .Select(x => x ? RunKeyFrames(animation, control, onComplete) : Disposable.Empty)
+                        .Select(x => x ? RunKeyFrames(animation, control, onComplete) : null)
                         .DisposeCurrentOnNext()
                         .Subscribe();
         }
@@ -172,4 +169,4 @@ namespace Avalonia.Animation
             }
         }
     }
-}
+}

src/Avalonia.Base/Reactive/DisposeOnNextObservable.cs

@@ -9,9 +9,9 @@ namespace Avalonia.Reactive
 
         private void ValueNext(T value)
         {
-            this.PublishNext(value);
             lastValue?.Dispose();
             lastValue = value;
+            this.PublishNext(value);
         }
 
         public void OnCompleted()