diff --git a/src/Avalonia.Controls/ItemsControl.cs b/src/Avalonia.Controls/ItemsControl.cs
index 256160a116..56b0014c05 100644
--- a/src/Avalonia.Controls/ItemsControl.cs
+++ b/src/Avalonia.Controls/ItemsControl.cs
@@ -518,7 +518,7 @@ namespace Avalonia.Controls
                 }
 
                 c = result;
-            } while (c != null && c != from);
+            } while (c != null && c != from && direction != NavigationDirection.First && direction != NavigationDirection.Last);
 
             return null;
         }
diff --git a/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs b/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs
index 6e9ac537f1..2f9bf0ac06 100644
--- a/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs
+++ b/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs
@@ -417,7 +417,7 @@ namespace Avalonia.Controls.Platform
 
         protected internal virtual void MenuOpened(object? sender, RoutedEventArgs e)
         {
-            if (e.Source == Menu)
+            if (e.Source is Menu)
             {
                 Menu?.MoveSelection(NavigationDirection.First, true);
             }
diff --git a/tests/Avalonia.Controls.UnitTests/Primitives/SelectingItemsControlTests.cs b/tests/Avalonia.Controls.UnitTests/Primitives/SelectingItemsControlTests.cs
index 0e0ca7cd25..3d36395c3a 100644
--- a/tests/Avalonia.Controls.UnitTests/Primitives/SelectingItemsControlTests.cs
+++ b/tests/Avalonia.Controls.UnitTests/Primitives/SelectingItemsControlTests.cs
@@ -6,6 +6,7 @@ using System.Collections.Specialized;
 using System.ComponentModel;
 using System.Linq;
 using System.Reactive.Disposables;
+using System.Threading.Tasks;
 using Avalonia.Collections;
 using Avalonia.Controls.Presenters;
 using Avalonia.Controls.Primitives;
@@ -1614,6 +1615,50 @@ namespace Avalonia.Controls.UnitTests.Primitives
             target.MoveSelection(NavigationDirection.Next, true);
         }
 
+        [Fact(Timeout = 2000)]
+        public async Task MoveSelection_Does_Not_Hang_With_No_Focusable_Controls_And_Moving_Selection_To_The_First_Item()
+        {
+            var target = new TestSelector
+            {
+                Template = Template(),
+                Items = new[]
+                {
+                    new ListBoxItem { Focusable = false },
+                    new ListBoxItem(),
+                }
+            };
+
+            target.Measure(new Size(100, 100));
+            target.Arrange(new Rect(0, 0, 100, 100));
+
+            // Timeout in xUnit doesen't work with synchronous methods so we need to apply hack below.
+            // https://github.com/xunit/xunit/issues/2222
+            await Task.Run(() => target.MoveSelection(NavigationDirection.First, true));
+            Assert.Equal(-1, target.SelectedIndex);
+        }
+
+        [Fact(Timeout = 2000)]
+        public async Task MoveSelection_Does_Not_Hang_With_No_Focusable_Controls_And_Moving_Selection_To_The_Last_Item()
+        {
+            var target = new TestSelector
+            {
+                Template = Template(),
+                Items = new[]
+                {
+                    new ListBoxItem(),
+                    new ListBoxItem { Focusable = false },
+                }
+            };
+
+            target.Measure(new Size(100, 100));
+            target.Arrange(new Rect(0, 0, 100, 100));
+
+            // Timeout in xUnit doesen't work with synchronous methods so we need to apply hack below.
+            // https://github.com/xunit/xunit/issues/2222
+            await Task.Run(() => target.MoveSelection(NavigationDirection.Last, true));
+            Assert.Equal(-1, target.SelectedIndex);
+        }
+
         [Fact]
         public void MoveSelection_Does_Select_Disabled_Controls()
         {