diff --git a/src/Avalonia.Controls/ListBox.cs b/src/Avalonia.Controls/ListBox.cs
index 80b5259a53..86118d7b00 100644
--- a/src/Avalonia.Controls/ListBox.cs
+++ b/src/Avalonia.Controls/ListBox.cs
@@ -139,7 +139,8 @@ namespace Avalonia.Controls
                     e.Source,
                     true,
                     e.KeyModifiers.HasAllFlags(KeyModifiers.Shift),
-                    e.KeyModifiers.HasAllFlags(KeyModifiers.Control));
+                    e.KeyModifiers.HasAllFlags(KeyModifiers.Control),
+                    fromFocus: true);
             }
         }
 
diff --git a/src/Avalonia.Controls/Primitives/SelectingItemsControl.cs b/src/Avalonia.Controls/Primitives/SelectingItemsControl.cs
index ea20247b4b..e03b02a479 100644
--- a/src/Avalonia.Controls/Primitives/SelectingItemsControl.cs
+++ b/src/Avalonia.Controls/Primitives/SelectingItemsControl.cs
@@ -586,6 +586,14 @@ namespace Avalonia.Controls.Primitives
                     Selection.SelectAll();
                     e.Handled = true;
                 }
+                else if (e.Key == Key.Space || e.Key == Key.Enter)
+                {
+                    e.Handled = UpdateSelectionFromEventSource(
+                          e.Source,
+                          true,
+                          e.KeyModifiers.HasFlag(KeyModifiers.Shift),
+                          e.KeyModifiers.HasFlag(KeyModifiers.Control));
+                }
             }
         }
 
@@ -662,12 +670,14 @@ namespace Avalonia.Controls.Primitives
         /// <param name="rangeModifier">Whether the range modifier is enabled (i.e. shift key).</param>
         /// <param name="toggleModifier">Whether the toggle modifier is enabled (i.e. ctrl key).</param>
         /// <param name="rightButton">Whether the event is a right-click.</param>
+        /// <param name="fromFocus">Wheter the event is a focus event</param>
         protected void UpdateSelection(
             int index,
             bool select = true,
             bool rangeModifier = false,
             bool toggleModifier = false,
-            bool rightButton = false)
+            bool rightButton = false,
+            bool fromFocus = false)
         {
             if (index < 0 || index >= ItemCount)
             {
@@ -696,22 +706,25 @@ namespace Avalonia.Controls.Primitives
                 Selection.Clear();
                 Selection.SelectRange(Selection.AnchorIndex, index);
             }
-            else if (multi && toggle)
+            else if (!fromFocus && toggle)
             {
-                if (Selection.IsSelected(index) == true)
+                if (multi)
                 {
-                    Selection.Deselect(index);
+                    if (Selection.IsSelected(index) == true)
+                    {
+                        Selection.Deselect(index);
+                    }
+                    else
+                    {
+                        Selection.Select(index);
+                    }
                 }
                 else
                 {
-                    Selection.Select(index);
+                    SelectedIndex = (SelectedIndex == index) ? -1 : index;
                 }
             }
-            else if (toggle)
-            {
-                SelectedIndex = (SelectedIndex == index) ? -1 : index;
-            }
-            else
+            else if (!toggle)
             {
                 using var operation = Selection.BatchUpdate();
                 Selection.Clear();
@@ -735,18 +748,20 @@ namespace Avalonia.Controls.Primitives
         /// <param name="rangeModifier">Whether the range modifier is enabled (i.e. shift key).</param>
         /// <param name="toggleModifier">Whether the toggle modifier is enabled (i.e. ctrl key).</param>
         /// <param name="rightButton">Whether the event is a right-click.</param>
+        /// <param name="fromFocus">Wheter the event is a focus event</param>
         protected void UpdateSelection(
             IControl container,
             bool select = true,
             bool rangeModifier = false,
             bool toggleModifier = false,
-            bool rightButton = false)
+            bool rightButton = false,
+            bool fromFocus = false)
         {
             var index = ItemContainerGenerator?.IndexFromContainer(container) ?? -1;
 
             if (index != -1)
             {
-                UpdateSelection(index, select, rangeModifier, toggleModifier, rightButton);
+                UpdateSelection(index, select, rangeModifier, toggleModifier, rightButton, fromFocus);
             }
         }
 
@@ -759,6 +774,7 @@ namespace Avalonia.Controls.Primitives
         /// <param name="rangeModifier">Whether the range modifier is enabled (i.e. shift key).</param>
         /// <param name="toggleModifier">Whether the toggle modifier is enabled (i.e. ctrl key).</param>
         /// <param name="rightButton">Whether the event is a right-click.</param>
+        /// <param name="fromFocus">Wheter the event is a focus event</param>
         /// <returns>
         /// True if the event originated from a container that belongs to the control; otherwise
         /// false.
@@ -768,13 +784,14 @@ namespace Avalonia.Controls.Primitives
             bool select = true,
             bool rangeModifier = false,
             bool toggleModifier = false,
-            bool rightButton = false)
+            bool rightButton = false,
+            bool fromFocus = false)
         {
             var container = GetContainerFromEventSource(eventSource);
 
             if (container != null)
             {
-                UpdateSelection(container, select, rangeModifier, toggleModifier, rightButton);
+                UpdateSelection(container, select, rangeModifier, toggleModifier, rightButton, fromFocus);
                 return true;
             }
 
diff --git a/tests/Avalonia.Controls.UnitTests/ListBoxTests_Multiple.cs b/tests/Avalonia.Controls.UnitTests/ListBoxTests_Multiple.cs
index 7c7cdd08db..556959effb 100644
--- a/tests/Avalonia.Controls.UnitTests/ListBoxTests_Multiple.cs
+++ b/tests/Avalonia.Controls.UnitTests/ListBoxTests_Multiple.cs
@@ -36,7 +36,7 @@ namespace Avalonia.Controls.UnitTests
         }
 
         [Fact]
-        public void Focusing_Item_With_Ctrl_And_Arrow_Key_Should_Add_To_Selection()
+        public void Focusing_Item_With_Ctrl_And_Arrow_Key_Should_Not_Add_To_Selection()
         {
             var target = new ListBox
             {
@@ -56,11 +56,11 @@ namespace Avalonia.Controls.UnitTests
                 KeyModifiers = KeyModifiers.Control
             });
 
-            Assert.Equal(new[] { "Foo", "Bar" }, target.SelectedItems);
+            Assert.Equal(new[] { "Foo" }, target.SelectedItems);
         }
 
         [Fact]
-        public void Focusing_Selected_Item_With_Ctrl_And_Arrow_Key_Should_Remove_From_Selection()
+        public void Focusing_Selected_Item_With_Ctrl_And_Arrow_Key_Should_Not_Remove_From_Selection()
         {
             var target = new ListBox
             {
@@ -81,7 +81,7 @@ namespace Avalonia.Controls.UnitTests
                 KeyModifiers = KeyModifiers.Control
             });
 
-            Assert.Equal(new[] { "Bar" }, target.SelectedItems);
+            Assert.Equal(new[] { "Foo", "Bar" }, target.SelectedItems);
         }
 
         private Control CreateListBoxTemplate(ITemplatedControl parent, INameScope scope)
diff --git a/tests/Avalonia.Controls.UnitTests/ListBoxTests_Single.cs b/tests/Avalonia.Controls.UnitTests/ListBoxTests_Single.cs
index bf516748cc..726a39ac46 100644
--- a/tests/Avalonia.Controls.UnitTests/ListBoxTests_Single.cs
+++ b/tests/Avalonia.Controls.UnitTests/ListBoxTests_Single.cs
@@ -59,6 +59,58 @@ namespace Avalonia.Controls.UnitTests
             Assert.Equal(0, target.SelectedIndex);
         }
 
+        [Fact]
+        public void Focusing_Item_With_Arrow_Key_And_Ctrl_Pressed_Should_Not_Select_It()
+        {
+            var target = new ListBox
+            {
+                Template = new FuncControlTemplate(CreateListBoxTemplate),
+                Items = new[] { "Foo", "Bar", "Baz " },
+            };
+
+            ApplyTemplate(target);
+
+            target.Presenter.Panel.Children[0].RaiseEvent(new GotFocusEventArgs
+            {
+                RoutedEvent = InputElement.GotFocusEvent,
+                NavigationMethod = NavigationMethod.Directional,
+                KeyModifiers = KeyModifiers.Control
+            });
+
+            Assert.Equal(-1, target.SelectedIndex);
+        }
+
+        [Fact]
+        public void Pressing_Space_On_Focused_Item_With_Ctrl_Pressed_Should_Select_It()
+        {
+            using (UnitTestApplication.Start())
+            {
+                var target = new ListBox
+                {
+                    Template = new FuncControlTemplate(CreateListBoxTemplate),
+                    Items = new[] { "Foo", "Bar", "Baz " },
+                };
+                AvaloniaLocator.CurrentMutable.Bind<PlatformHotkeyConfiguration>().ToConstant(new Mock<PlatformHotkeyConfiguration>().Object);
+                ApplyTemplate(target);
+
+                target.Presenter.Panel.Children[0].RaiseEvent(new GotFocusEventArgs
+                {
+                    RoutedEvent = InputElement.GotFocusEvent,
+                    NavigationMethod = NavigationMethod.Directional,
+                    KeyModifiers = KeyModifiers.Control
+                });
+
+                target.Presenter.Panel.Children[0].RaiseEvent(new KeyEventArgs
+                {
+                    RoutedEvent = InputElement.KeyDownEvent,
+                    Key = Key.Space,
+                    KeyModifiers = KeyModifiers.Control
+                });
+
+                Assert.Equal(0, target.SelectedIndex);
+            }
+        }
+
         [Fact]
         public void Clicking_Item_Should_Select_It()
         {