diff --git a/src/Markup/Avalonia.Markup/Avalonia.Markup.csproj b/src/Markup/Avalonia.Markup/Avalonia.Markup.csproj
index 5bdbb5a827..5826346fc9 100644
--- a/src/Markup/Avalonia.Markup/Avalonia.Markup.csproj
+++ b/src/Markup/Avalonia.Markup/Avalonia.Markup.csproj
@@ -42,6 +42,7 @@
     <Compile Include="..\..\Shared\SharedAssemblyInfo.cs">
       <Link>Properties\SharedAssemblyInfo.cs</Link>
     </Compile>
+    <Compile Include="Data\ISettableNode.cs" />
     <Compile Include="Data\StreamNode.cs" />
     <Compile Include="Data\MarkupBindingChainException.cs" />
     <Compile Include="Data\CommonPropertyNames.cs" />
diff --git a/src/Markup/Avalonia.Markup/Data/ExpressionObserver.cs b/src/Markup/Avalonia.Markup/Data/ExpressionObserver.cs
index 37226ee74b..7ad8486bdd 100644
--- a/src/Markup/Avalonia.Markup/Data/ExpressionObserver.cs
+++ b/src/Markup/Avalonia.Markup/Data/ExpressionObserver.cs
@@ -153,7 +153,7 @@ namespace Avalonia.Markup.Data
         /// </returns>
         public bool SetValue(object value, BindingPriority priority = BindingPriority.LocalValue)
         {
-            return (Leaf as PropertyAccessorNode)?.SetTargetValue(value, priority) ?? false;
+            return (Leaf as ISettableNode)?.SetTargetValue(value, priority) ?? false;
         }
 
         /// <summary>
@@ -170,7 +170,7 @@ namespace Avalonia.Markup.Data
         /// Gets the type of the expression result or null if the expression could not be 
         /// evaluated.
         /// </summary>
-        public Type ResultType => (Leaf as PropertyAccessorNode)?.PropertyType;
+        public Type ResultType => (Leaf as ISettableNode)?.PropertyType;
 
         /// <summary>
         /// Gets the leaf node.
diff --git a/src/Markup/Avalonia.Markup/Data/ISettableNode.cs b/src/Markup/Avalonia.Markup/Data/ISettableNode.cs
new file mode 100644
index 0000000000..8ee4f1de20
--- /dev/null
+++ b/src/Markup/Avalonia.Markup/Data/ISettableNode.cs
@@ -0,0 +1,15 @@
+using Avalonia.Data;
+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace Avalonia.Markup.Data
+{
+    interface ISettableNode
+    {
+        bool SetTargetValue(object value, BindingPriority priority);
+        Type PropertyType { get; }
+    }
+}
diff --git a/src/Markup/Avalonia.Markup/Data/IndexerNode.cs b/src/Markup/Avalonia.Markup/Data/IndexerNode.cs
index 0a6b93bad1..8ab665c4a4 100644
--- a/src/Markup/Avalonia.Markup/Data/IndexerNode.cs
+++ b/src/Markup/Avalonia.Markup/Data/IndexerNode.cs
@@ -11,10 +11,11 @@ using System.Globalization;
 using System.Linq;
 using System.Reflection;
 using System.Reactive.Linq;
+using Avalonia.Data;
 
 namespace Avalonia.Markup.Data
 {
-    internal class IndexerNode : ExpressionNode
+    internal class IndexerNode : ExpressionNode, ISettableNode
     {
         public IndexerNode(IList<string> arguments)
         {
@@ -51,8 +52,110 @@ namespace Avalonia.Markup.Data
             return Observable.Merge(inputs).StartWith(GetValue(target));
         }
 
+        public bool SetTargetValue(object value, BindingPriority priority)
+        {
+            var typeInfo = Target.Target.GetType().GetTypeInfo();
+            var list = Target.Target as IList;
+            var dictionary = Target.Target as IDictionary;
+            var indexerProperty = GetIndexer(typeInfo);
+            var indexerParameters = indexerProperty?.GetIndexParameters();
+
+            if (indexerProperty != null && indexerParameters.Length == Arguments.Count)
+            {
+                var convertedObjectArray = new object[indexerParameters.Length];
+
+                for (int i = 0; i < Arguments.Count; i++)
+                {
+                    object temp = null;
+
+                    if (!TypeUtilities.TryConvert(indexerParameters[i].ParameterType, Arguments[i], CultureInfo.InvariantCulture, out temp))
+                    {
+                        return false;
+                    }
+
+                    convertedObjectArray[i] = temp;
+                }
+
+                var intArgs = convertedObjectArray.OfType<int>().ToArray();
+
+                // Try special cases where we can validate indicies
+                if (typeInfo.IsArray)
+                {
+                    return SetValueInArray((Array)Target.Target, intArgs, value);
+                }
+                else if (Arguments.Count == 1)
+                {
+                    if (list != null)
+                    {
+                        if (intArgs.Length == Arguments.Count && intArgs[0] >= 0 && intArgs[0] < list.Count)
+                        {
+                            list[intArgs[0]] = value;
+                            return true;
+                        }
+
+                        return false;
+                    }
+                    else if (dictionary != null)
+                    {
+                        if (dictionary.Contains(convertedObjectArray[0]))
+                        {
+                            dictionary[convertedObjectArray[0]] = value;
+                            return true;
+                        }
+                        else
+                        {
+                            dictionary.Add(convertedObjectArray[0], value);
+                            return true;
+                        }
+                    }
+                    else
+                    {
+                        // Fallback to unchecked access
+                        indexerProperty.SetValue(Target.Target, value, convertedObjectArray);
+                        return true;
+                    }
+                }
+                else
+                {
+                    // Fallback to unchecked access
+                    indexerProperty.SetValue(Target.Target, value, convertedObjectArray);
+                    return true;
+                }
+            }
+            // Multidimensional arrays end up here because the indexer search picks up the IList indexer instead of the
+            // multidimensional indexer, which doesn't take the same number of arguments
+            else if (typeInfo.IsArray)
+            {
+                SetValueInArray((Array)Target.Target, value);
+                return true;
+            }
+            return false;
+        }
+
+        private bool SetValueInArray(Array array, object value)
+        {
+            int[] intArgs;
+            if (!ConvertArgumentsToInts(out intArgs))
+                return false;
+            return SetValueInArray(array, intArgs);
+        }
+
+
+        private bool SetValueInArray(Array array, int[] indicies, object value)
+        {
+            if (ValidBounds(indicies, array))
+            {
+                array.SetValue(value, indicies);
+                return true;
+            }
+            return false;
+        }
+
+
         public IList<string> Arguments { get; }
 
+        public Type PropertyType => GetIndexer(Target.Target.GetType().GetTypeInfo())?.PropertyType;
+
         private object GetValue(object target)
         {
             var typeInfo = target.GetType().GetTypeInfo();
@@ -238,7 +341,7 @@ namespace Avalonia.Markup.Data
                 }
             }
 
-            return false;
+            return true; // Implementation defined meaning for the index, so just try to update anyway
         }
 
         private bool ShouldUpdate(object sender, PropertyChangedEventArgs e)
diff --git a/src/Markup/Avalonia.Markup/Data/PropertyAccessorNode.cs b/src/Markup/Avalonia.Markup/Data/PropertyAccessorNode.cs
index 7fb3137417..ab80d72215 100644
--- a/src/Markup/Avalonia.Markup/Data/PropertyAccessorNode.cs
+++ b/src/Markup/Avalonia.Markup/Data/PropertyAccessorNode.cs
@@ -10,7 +10,7 @@ using Avalonia.Markup.Data.Plugins;
 
 namespace Avalonia.Markup.Data
 {
-    internal class PropertyAccessorNode : ExpressionNode
+    internal class PropertyAccessorNode : ExpressionNode, ISettableNode
     {
         private readonly bool _enableValidation;
         private IPropertyAccessor _accessor;
diff --git a/tests/Avalonia.Markup.UnitTests/Data/BindingExpressionTests.cs b/tests/Avalonia.Markup.UnitTests/Data/BindingExpressionTests.cs
index f93caa4adf..8770ae560c 100644
--- a/tests/Avalonia.Markup.UnitTests/Data/BindingExpressionTests.cs
+++ b/tests/Avalonia.Markup.UnitTests/Data/BindingExpressionTests.cs
@@ -37,6 +37,17 @@ namespace Avalonia.Markup.UnitTests.Data
             Assert.Equal("bar", data.StringValue);
         }
 
+        [Fact]
+        public void Should_Set_Indexed_Value()
+        {
+            var data = new { Foo = new[] { "foo" } };
+            var target = new BindingExpression(new ExpressionObserver(data, "Foo[0]"), typeof(string));
+
+            target.OnNext("bar");
+
+            Assert.Equal("bar", data.Foo[0]);
+        }
+
         [Fact]
         public async void Should_Convert_Get_String_To_Double()
         {
diff --git a/tests/Avalonia.Markup.UnitTests/Data/ExpressionObserverTests_Indexer.cs b/tests/Avalonia.Markup.UnitTests/Data/ExpressionObserverTests_Indexer.cs
index f6c4540611..9c7d0347a6 100644
--- a/tests/Avalonia.Markup.UnitTests/Data/ExpressionObserverTests_Indexer.cs
+++ b/tests/Avalonia.Markup.UnitTests/Data/ExpressionObserverTests_Indexer.cs
@@ -192,6 +192,79 @@ namespace Avalonia.Markup.UnitTests.Data
             Assert.Equal(0, data.Foo.PropertyChangedSubscriptionCount);
         }
 
+        [Fact]
+        public void Should_SetArrayIndex()
+        {
+            var data = new { Foo = new[] { "foo", "bar" } };
+            var target = new ExpressionObserver(data, "Foo[1]");
+
+            using (target.Subscribe(_ => { }))
+            {
+                Assert.True(target.SetValue("baz"));
+            }
+
+            Assert.Equal("baz", data.Foo[1]);
+        }
+
+        [Fact]
+        public void Should_Set_ExistingDictionaryEntry()
+        {
+            var data = new
+            {
+                Foo = new Dictionary<string, int>
+                {
+                    {"foo", 1 }
+                }
+            };
+
+
+            var target = new ExpressionObserver(data, "Foo[foo]");
+            using (target.Subscribe(_ => { }))
+            {
+                Assert.True(target.SetValue(4));
+            }
+
+            Assert.Equal(4, data.Foo["foo"]);
+        }
+
+        [Fact]
+        public void Should_Add_NewDictionaryEntry()
+        {
+            var data = new
+            {
+                Foo = new Dictionary<string, int>
+                {
+                    {"foo", 1 }
+                }
+            };
+
+
+            var target = new ExpressionObserver(data, "Foo[bar]");
+            using (target.Subscribe(_ => { }))
+            {
+                Assert.True(target.SetValue(4));
+            }
+
+            Assert.Equal(4, data.Foo["bar"]);
+        }
+
+        [Fact]
+        public void Should_Set_NonIntegerIndexer()
+        {
+            var data = new { Foo = new NonIntegerIndexer() };
+            data.Foo["foo"] = "bar";
+            data.Foo["baz"] = "qux";
+
+            var target = new ExpressionObserver(data, "Foo[foo]");
+
+            using (target.Subscribe(_ => { }))
+            {
+                Assert.True(target.SetValue("bar2"));
+            }
+            
+            Assert.Equal("bar2", data.Foo["foo"]);
+        }
+
         private class NonIntegerIndexer : NotifyingBase
         {
             private readonly Dictionary<string, string> _storage = new Dictionary<string, string>();