diff --git a/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/AvaloniaXamlIlCompiler.cs b/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/AvaloniaXamlIlCompiler.cs
index 1ca7be67a7..7514b0e12e 100644
--- a/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/AvaloniaXamlIlCompiler.cs
+++ b/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/AvaloniaXamlIlCompiler.cs
@@ -31,10 +31,10 @@ namespace Avalonia.Markup.Xaml.XamlIl.CompilerExtensions
             // Before everything else
             
             Transformers.Insert(0, new XNameTransformer());
-            Transformers.Insert(1, new IgnoredDirectivesTransformer());
-            Transformers.Insert(2, _designTransformer = new AvaloniaXamlIlDesignPropertiesTransformer());
-            Transformers.Insert(3, _bindingTransformer = new AvaloniaBindingExtensionTransformer());
-            
+            Transformers.Insert(1, new XDataTypeTransformer());
+            Transformers.Insert(2, new IgnoredDirectivesTransformer());
+            Transformers.Insert(3, _designTransformer = new AvaloniaXamlIlDesignPropertiesTransformer());
+            Transformers.Insert(4, _bindingTransformer = new AvaloniaBindingExtensionTransformer());
             
             // Targeted
             InsertBefore<PropertyReferenceResolver>(
diff --git a/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/Transformers/XDataTypeTransformer.cs b/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/Transformers/XDataTypeTransformer.cs
new file mode 100644
index 0000000000..7b90164974
--- /dev/null
+++ b/src/Markup/Avalonia.Markup.Xaml.Loader/CompilerExtensions/Transformers/XDataTypeTransformer.cs
@@ -0,0 +1,79 @@
+using System.Collections.Generic;
+using System.Linq;
+using XamlX;
+using XamlX.Ast;
+using XamlX.Transform;
+using XamlX.Transform.Transformers;
+using XamlX.TypeSystem;
+
+namespace Avalonia.Markup.Xaml.XamlIl.CompilerExtensions.Transformers
+{
+    internal class XDataTypeTransformer : IXamlAstTransformer
+    {
+        private const string DataTypePropertyName = "DataType";
+        
+        /// <summary>
+        /// Converts x:DataType directives to regular DataType assignments if property with Avalonia.Metadata.DataTypeAttribute exists.
+        /// </summary>
+        /// <returns></returns>
+        public IXamlAstNode Transform(AstTransformationContext context, IXamlAstNode node)
+        {
+            if (node is XamlAstObjectNode on)
+            {
+                for (var c = 0; c < on.Children.Count; c++)
+                {
+                    var ch = on.Children[c];
+                    if (ch is XamlAstXmlDirective { Namespace: XamlNamespaces.Xaml2006, Name: DataTypePropertyName } d)
+                    {
+                        if (on.Children.OfType<XamlAstXamlPropertyValueNode>()
+                            .Any(p => ((XamlAstNamePropertyReference)p.Property)?.Name == DataTypePropertyName))
+                        {
+                            // Break iteration if any DataType property was already set by user code.
+                            break;
+                        }
+                        
+                        var templateDataTypeAttribute = context.GetAvaloniaTypes().DataTypeAttribute;
+
+                        var clrType = on.Type switch
+                        {
+                            XamlAstClrTypeReference clrRef => clrRef.Type,
+                            XamlAstXmlTypeReference xmlRef => TypeReferenceResolver.ResolveType(context, xmlRef.Name,
+                                on.Type.IsMarkupExtension, on, strict: false).Type,
+                            _ => null
+                        };
+                        if (clrType is null)
+                        {
+                            break;
+                        }
+
+                        // Technically it's possible to map "x:DataType" to a property with [DataType] attribute regardless of its name,
+                        // but we go explicitly strict here and check the name as well.
+                        var (declaringType, dataTypeProperty) = GetAllProperties(clrType)
+                            .FirstOrDefault(t => t.property.Name == DataTypePropertyName && t.property.CustomAttributes
+                                .Any(a => a.Type == templateDataTypeAttribute));
+                       
+                        if (dataTypeProperty is not null)
+                        {
+                            on.Children[c] = new XamlAstXamlPropertyValueNode(d,
+                                new XamlAstNamePropertyReference(d,
+                                    new XamlAstClrTypeReference(ch, declaringType, false), dataTypeProperty.Name,
+                                    on.Type),
+                                d.Values);
+                        }
+                    }
+                }
+            }
+
+            return node;
+        }
+        
+        private static IEnumerable<(IXamlType declaringType, IXamlProperty property)> GetAllProperties(IXamlType t)
+        {
+            foreach (var p in t.Properties)
+                yield return (t, p);
+            if(t.BaseType!=null)
+                foreach (var tuple in GetAllProperties(t.BaseType))
+                    yield return tuple;
+        }
+    }
+}
diff --git a/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/DataTemplateTests.cs b/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/DataTemplateTests.cs
index 53881467e7..f9e1ce3054 100644
--- a/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/DataTemplateTests.cs
+++ b/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/DataTemplateTests.cs
@@ -1,5 +1,7 @@
+using System.Linq;
 using Avalonia.Controls;
 using Avalonia.Controls.Presenters;
+using Avalonia.Markup.Xaml.Templates;
 using Avalonia.UnitTests;
 using Xunit;
 
@@ -89,6 +91,62 @@ namespace Avalonia.Markup.Xaml.UnitTests.Xaml
             }
         }
 
+        [Fact]
+        public void XDataType_Should_Be_Assigned_To_Clr_Property()
+        {
+            using (UnitTestApplication.Start(TestServices.StyledWindow))
+            {
+                var xaml = @"
+<Window xmlns='https://github.com/avaloniaui'
+        xmlns:sys='clr-namespace:System;assembly=netstandard'
+        xmlns:x='http://schemas.microsoft.com/winfx/2006/xaml'>
+    <Window.DataTemplates>
+        <DataTemplate x:DataType='sys:String'>
+            <Canvas Name='foo'/>
+        </DataTemplate>
+    </Window.DataTemplates>
+    <ContentControl Name='target' Content='Foo'/>
+</Window>";
+                var window = (Window)AvaloniaRuntimeXamlLoader.Load(xaml);
+                var target = window.FindControl<ContentControl>("target");
+                var template = (DataTemplate)window.DataTemplates.First();
+                
+                window.ApplyTemplate();
+                target.ApplyTemplate();
+                ((ContentPresenter)target.Presenter).UpdateChild();
+                
+                Assert.Equal(typeof(string), template.DataType);
+                Assert.IsType<Canvas>(target.Presenter.Child);
+            }
+        }
+        
+        [Fact]
+        public void XDataType_Should_Be_Ignored_If_DataType_Already_Set()
+        {
+            using (UnitTestApplication.Start(TestServices.StyledWindow))
+            {
+                var xaml = @"
+<Window xmlns='https://github.com/avaloniaui'
+        xmlns:sys='clr-namespace:System;assembly=netstandard'
+        xmlns:x='http://schemas.microsoft.com/winfx/2006/xaml'>
+    <Window.DataTemplates>
+        <DataTemplate DataType='sys:String' x:DataType='UserControl'>
+            <Canvas Name='foo'/>
+        </DataTemplate>
+    </Window.DataTemplates>
+    <ContentControl Name='target' Content='Foo'/>
+</Window>";
+                var window = (Window)AvaloniaRuntimeXamlLoader.Load(xaml);
+                var target = window.FindControl<ContentControl>("target");
+
+                window.ApplyTemplate();
+                target.ApplyTemplate();
+                ((ContentPresenter)target.Presenter).UpdateChild();
+
+                Assert.IsType<Canvas>(target.Presenter.Child);
+            }
+        }
+        
         [Fact]
         public void Can_Set_DataContext_In_DataTemplate()
         {
diff --git a/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/TreeDataTemplateTests.cs b/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/TreeDataTemplateTests.cs
index 3fdac49f31..d4ab473d67 100644
--- a/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/TreeDataTemplateTests.cs
+++ b/tests/Avalonia.Markup.Xaml.UnitTests/Xaml/TreeDataTemplateTests.cs
@@ -21,5 +21,22 @@ namespace Avalonia.Markup.Xaml.UnitTests.Xaml
                 Assert.IsType<Binding>(template.ItemsSource);
             }                
         }
+        
+        [Fact]
+        public void XDataType_Should_Be_Assigned_To_Clr_Property()
+        {
+            using (UnitTestApplication.Start(TestServices.MockPlatformWrapper))
+            {
+                var xaml = @"
+<DataTemplates xmlns='https://github.com/avaloniaui'
+               xmlns:x='http://schemas.microsoft.com/winfx/2006/xaml'>
+    <TreeDataTemplate x:DataType='x:String' />
+</DataTemplates>";
+                var templates = (DataTemplates)AvaloniaRuntimeXamlLoader.Load(xaml);
+                var template = (TreeDataTemplate)(templates.First());
+
+                Assert.Equal(typeof(string), template.DataType);
+            }                
+        }
     }
 }