diff --git a/src/Avalonia.Controls/ComboBox.cs b/src/Avalonia.Controls/ComboBox.cs
index f8728af87f..dd2109e6cd 100644
--- a/src/Avalonia.Controls/ComboBox.cs
+++ b/src/Avalonia.Controls/ComboBox.cs
@@ -205,7 +205,7 @@ namespace Avalonia.Controls
             if (e.Handled)
                 return;
 
-            if (e.Key == Key.F4 ||
+            if ((e.Key == Key.F4 && e.KeyModifiers.HasAllFlags(KeyModifiers.Alt) == false) ||
                 ((e.Key == Key.Down || e.Key == Key.Up) && e.KeyModifiers.HasAllFlags(KeyModifiers.Alt)))
             {
                 IsDropDownOpen = !IsDropDownOpen;