diff --git a/src/ImageSharp/Common/Helpers/DebugGuard.cs b/src/ImageSharp/Common/Helpers/DebugGuard.cs
index 096f96f04b..f6941fc6fc 100644
--- a/src/ImageSharp/Common/Helpers/DebugGuard.cs
+++ b/src/ImageSharp/Common/Helpers/DebugGuard.cs
@@ -170,6 +170,7 @@ namespace ImageSharp
         /// <exception cref="ArgumentException">
         /// <paramref name="target"/> is true
         /// </exception>
+        [Conditional("DEBUG")]
         public static void MustBeSameSized<T>(Span<T> target, Span<T> other, string parameterName)
             where T : struct
         {
@@ -189,6 +190,7 @@ namespace ImageSharp
         /// <exception cref="ArgumentException">
         /// <paramref name="target"/> is true
         /// </exception>
+        [Conditional("DEBUG")]
         public static void MustBeSizedAtLeast<T>(Span<T> target, Span<T> minSpan, string parameterName)
             where T : struct
         {
diff --git a/src/ImageSharp/Common/Helpers/Guard.cs b/src/ImageSharp/Common/Helpers/Guard.cs
index cf307e9365..a4b392fcf1 100644
--- a/src/ImageSharp/Common/Helpers/Guard.cs
+++ b/src/ImageSharp/Common/Helpers/Guard.cs
@@ -230,5 +230,24 @@ namespace ImageSharp
                 throw new ArgumentException(message, parameterName);
             }
         }
+
+        /// <summary>
+        /// Verifies, that the `target` span has the length of 'minSpan', or longer.
+        /// </summary>
+        /// <typeparam name="T">The element type of the spans</typeparam>
+        /// <param name="target">The target span.</param>
+        /// <param name="minLength">The minimum length.</param>
+        /// <param name="parameterName">The name of the parameter that is to be checked.</param>
+        /// <exception cref="ArgumentException">
+        /// <paramref name="target"/> is true
+        /// </exception>
+        public static void MustBeSizedAtLeast<T>(Span<T> target, int minLength, string parameterName)
+            where T : struct
+        {
+            if (target.Length < minLength)
+            {
+                throw new ArgumentException($"Span-s must be at least of length {minLength}!", parameterName);
+            }
+        }
     }
 }
diff --git a/src/ImageSharp/PixelFormats/PixelOperations{TPixel}.cs b/src/ImageSharp/PixelFormats/PixelOperations{TPixel}.cs
index b92b86b410..993a11232a 100644
--- a/src/ImageSharp/PixelFormats/PixelOperations{TPixel}.cs
+++ b/src/ImageSharp/PixelFormats/PixelOperations{TPixel}.cs
@@ -30,6 +30,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void PackFromVector4(Span<Vector4> sourceVectors, Span<TPixel> destColors, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceVectors, count, nameof(sourceVectors));
+            Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
             ref Vector4 sourceRef = ref sourceVectors.DangerousGetPinnableReference();
             ref TPixel destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -49,6 +52,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void ToVector4(Span<TPixel> sourceColors, Span<Vector4> destVectors, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+            Guard.MustBeSizedAtLeast(destVectors, count, nameof(destVectors));
+
             ref TPixel sourceRef = ref sourceColors.DangerousGetPinnableReference();
             ref Vector4 destRef = ref destVectors.DangerousGetPinnableReference();
 
@@ -68,6 +74,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void PackFromXyzBytes(Span<byte> sourceBytes, Span<TPixel> destColors, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceBytes, count * 3, nameof(sourceBytes));
+            Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
             ref byte sourceRef = ref sourceBytes.DangerousGetPinnableReference();
             ref TPixel destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -91,6 +100,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void ToXyzBytes(Span<TPixel> sourceColors, Span<byte> destBytes, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+            Guard.MustBeSizedAtLeast(destBytes, count * 3, nameof(destBytes));
+
             ref TPixel sourceRef = ref sourceColors.DangerousGetPinnableReference();
 
             for (int i = 0; i < count; i++)
@@ -108,6 +120,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void PackFromXyzwBytes(Span<byte> sourceBytes, Span<TPixel> destColors, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceBytes, count * 4, nameof(sourceBytes));
+            Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
             ref byte sourceRef = ref sourceBytes.DangerousGetPinnableReference();
             ref TPixel destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -131,6 +146,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void ToXyzwBytes(Span<TPixel> sourceColors, Span<byte> destBytes, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+            Guard.MustBeSizedAtLeast(destBytes, count * 4, nameof(destBytes));
+
             ref TPixel sourceRef = ref sourceColors.DangerousGetPinnableReference();
 
             for (int i = 0; i < count; i++)
@@ -148,6 +166,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void PackFromZyxBytes(Span<byte> sourceBytes, Span<TPixel> destColors, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceBytes, count * 3, nameof(sourceBytes));
+            Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
             ref byte sourceRef = ref sourceBytes.DangerousGetPinnableReference();
             ref TPixel destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -171,6 +192,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void ToZyxBytes(Span<TPixel> sourceColors, Span<byte> destBytes, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+            Guard.MustBeSizedAtLeast(destBytes, count * 3, nameof(destBytes));
+
             ref TPixel sourceRef = ref sourceColors.DangerousGetPinnableReference();
 
             for (int i = 0; i < count; i++)
@@ -188,6 +212,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void PackFromZyxwBytes(Span<byte> sourceBytes, Span<TPixel> destColors, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceBytes, count * 4, nameof(sourceBytes));
+            Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
             ref byte sourceRef = ref sourceBytes.DangerousGetPinnableReference();
             ref TPixel destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -211,6 +238,9 @@ namespace ImageSharp.PixelFormats
         /// <param name="count">The number of pixels to convert.</param>
         internal virtual void ToZyxwBytes(Span<TPixel> sourceColors, Span<byte> destBytes, int count)
         {
+            Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+            Guard.MustBeSizedAtLeast(destBytes, count * 4, nameof(destBytes));
+
             ref TPixel sourceRef = ref sourceColors.DangerousGetPinnableReference();
 
             for (int i = 0; i < count; i++)
diff --git a/src/ImageSharp/PixelFormats/Rgba32.PixelOperations.cs b/src/ImageSharp/PixelFormats/Rgba32.PixelOperations.cs
index 168787ba7c..2ba663603e 100644
--- a/src/ImageSharp/PixelFormats/Rgba32.PixelOperations.cs
+++ b/src/ImageSharp/PixelFormats/Rgba32.PixelOperations.cs
@@ -93,6 +93,9 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override void ToVector4(Span<Rgba32> sourceColors, Span<Vector4> destVectors, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+                Guard.MustBeSizedAtLeast(destVectors, count, nameof(destVectors));
+
                 if (count < 256 || !Vector.IsHardwareAccelerated)
                 {
                     // Doesn't worth to bother with SIMD:
@@ -120,6 +123,9 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override void PackFromXyzBytes(Span<byte> sourceBytes, Span<Rgba32> destColors, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceBytes, count * 3, nameof(sourceBytes));
+                Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
                 ref RGB24 sourceRef = ref Unsafe.As<byte, RGB24>(ref sourceBytes.DangerousGetPinnableReference());
                 ref Rgba32 destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -136,6 +142,9 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override void ToXyzBytes(Span<Rgba32> sourceColors, Span<byte> destBytes, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+                Guard.MustBeSizedAtLeast(destBytes, count * 3, nameof(destBytes));
+
                 ref Rgba32 sourceRef = ref sourceColors.DangerousGetPinnableReference();
                 ref RGB24 destRef = ref Unsafe.As<byte, RGB24>(ref destBytes.DangerousGetPinnableReference());
 
@@ -151,18 +160,27 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override unsafe void PackFromXyzwBytes(Span<byte> sourceBytes, Span<Rgba32> destColors, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceBytes, count * 4, nameof(sourceBytes));
+                Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
                 SpanHelper.Copy(sourceBytes, destColors.AsBytes(), count * sizeof(Rgba32));
             }
 
             /// <inheritdoc />
             internal override unsafe void ToXyzwBytes(Span<Rgba32> sourceColors, Span<byte> destBytes, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+                Guard.MustBeSizedAtLeast(destBytes, count * 4, nameof(destBytes));
+
                 SpanHelper.Copy(sourceColors.AsBytes(), destBytes, count * sizeof(Rgba32));
             }
 
             /// <inheritdoc />
             internal override void PackFromZyxBytes(Span<byte> sourceBytes, Span<Rgba32> destColors, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceBytes, count * 3, nameof(sourceBytes));
+                Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
                 ref RGB24 sourceRef = ref Unsafe.As<byte, RGB24>(ref sourceBytes.DangerousGetPinnableReference());
                 ref Rgba32 destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -179,6 +197,9 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override void ToZyxBytes(Span<Rgba32> sourceColors, Span<byte> destBytes, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+                Guard.MustBeSizedAtLeast(destBytes, count * 3, nameof(destBytes));
+
                 ref Rgba32 sourceRef = ref sourceColors.DangerousGetPinnableReference();
                 ref RGB24 destRef = ref Unsafe.As<byte, RGB24>(ref destBytes.DangerousGetPinnableReference());
 
@@ -194,6 +215,9 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override void PackFromZyxwBytes(Span<byte> sourceBytes, Span<Rgba32> destColors, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceBytes, count * 4, nameof(sourceBytes));
+                Guard.MustBeSizedAtLeast(destColors, count, nameof(destColors));
+
                 ref RGBA32 sourceRef = ref Unsafe.As<byte, RGBA32>(ref sourceBytes.DangerousGetPinnableReference());
                 ref Rgba32 destRef = ref destColors.DangerousGetPinnableReference();
 
@@ -209,6 +233,9 @@ namespace ImageSharp
             /// <inheritdoc />
             internal override void ToZyxwBytes(Span<Rgba32> sourceColors, Span<byte> destBytes, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+                Guard.MustBeSizedAtLeast(destBytes, count * 4, nameof(destBytes));
+
                 ref Rgba32 sourceRef = ref sourceColors.DangerousGetPinnableReference();
                 ref RGBA32 destRef = ref Unsafe.As<byte, RGBA32>(ref destBytes.DangerousGetPinnableReference());
 
diff --git a/src/ImageSharp/PixelFormats/RgbaVector.PixelOperations.cs b/src/ImageSharp/PixelFormats/RgbaVector.PixelOperations.cs
index 5c7ee17ca7..ac25b7f149 100644
--- a/src/ImageSharp/PixelFormats/RgbaVector.PixelOperations.cs
+++ b/src/ImageSharp/PixelFormats/RgbaVector.PixelOperations.cs
@@ -23,6 +23,9 @@ namespace ImageSharp.PixelFormats
             /// <inheritdoc />
             internal override unsafe void ToVector4(Span<RgbaVector> sourceColors, Span<Vector4> destVectors, int count)
             {
+                Guard.MustBeSizedAtLeast(sourceColors, count, nameof(sourceColors));
+                Guard.MustBeSizedAtLeast(destVectors, count, nameof(destVectors));
+
                 SpanHelper.Copy(sourceColors.AsBytes(), destVectors.AsBytes(), count * sizeof(Vector4));
             }
         }