diff --git a/src/ImageSharp/Formats/Webp/Lossy/Vp8EncIterator.cs b/src/ImageSharp/Formats/Webp/Lossy/Vp8EncIterator.cs
index 79fd8d8543..489977cb82 100644
--- a/src/ImageSharp/Formats/Webp/Lossy/Vp8EncIterator.cs
+++ b/src/ImageSharp/Formats/Webp/Lossy/Vp8EncIterator.cs
@@ -2,6 +2,10 @@
 // Licensed under the Apache License, Version 2.0.
 
 using System;
+#if SUPPORTS_RUNTIME_INTRINSICS
+using System.Runtime.Intrinsics;
+using System.Runtime.Intrinsics.X86;
+#endif
 
 namespace SixLabors.ImageSharp.Formats.Webp.Lossy
 {
@@ -9,7 +13,7 @@ namespace SixLabors.ImageSharp.Formats.Webp.Lossy
     /// Iterator structure to iterate through macroblocks, pointing to the
     /// right neighbouring data (samples, predictions, contexts, ...)
     /// </summary>
-    internal class Vp8EncIterator
+    internal unsafe class Vp8EncIterator
     {
         public const int YOffEnc = 0;
 
@@ -29,6 +33,10 @@ namespace SixLabors.ImageSharp.Formats.Webp.Lossy
 
         private readonly int mbh;
 
+#if SUPPORTS_RUNTIME_INTRINSICS
+        private static readonly Vector128<byte> Mean16x4Mask = Vector128.Create(0x00ff).AsByte();
+#endif
+
         /// <summary>
         /// Stride of the prediction plane(=4*mbw + 1).
         /// </summary>
@@ -357,12 +365,13 @@ namespace SixLabors.ImageSharp.Formats.Webp.Lossy
             int q = quality;
             int kThreshold = 8 + ((17 - 8) * q / 100);
             int k;
-            uint[] dc = new uint[16];
+            Span<uint> dc = stackalloc uint[16];
+            Span<ushort> tmp = stackalloc ushort[16];
             uint m;
             uint m2;
             for (k = 0; k < 16; k += 4)
             {
-                this.Mean16x4(this.YuvIn.AsSpan(YOffEnc + (k * WebpConstants.Bps)), dc.AsSpan(k));
+                this.Mean16x4(this.YuvIn.AsSpan(YOffEnc + (k * WebpConstants.Bps)), dc.Slice(k, 4), tmp);
             }
 
             for (m = 0, m2 = 0, k = 0; k < 16; ++k)
@@ -823,21 +832,61 @@ namespace SixLabors.ImageSharp.Formats.Webp.Lossy
             this.Nz[this.nzIdx] = nz;
         }
 
-        private void Mean16x4(Span<byte> input, Span<uint> dc)
+        private void Mean16x4(Span<byte> input, Span<uint> dc, Span<ushort> tmp)
         {
-            for (int k = 0; k < 4; k++)
+#if SUPPORTS_RUNTIME_INTRINSICS
+            if (Sse2.IsSupported)
             {
-                uint avg = 0;
-                for (int y = 0; y < 4; y++)
+#pragma warning disable SA1503 // Braces should not be omitted
+                tmp.Clear();
+                fixed (byte* inputPtr = input)
+                fixed (ushort* tmpPtr = tmp)
                 {
-                    for (int x = 0; x < 4; x++)
+                    Vector128<byte> a0 = Sse2.LoadVector128(inputPtr);
+                    Vector128<byte> a1 = Sse2.LoadVector128(inputPtr + WebpConstants.Bps);
+                    Vector128<byte> a2 = Sse2.LoadVector128(inputPtr + (WebpConstants.Bps * 2));
+                    Vector128<byte> a3 = Sse2.LoadVector128(inputPtr + (WebpConstants.Bps * 3));
+                    Vector128<short> b0 = Sse2.ShiftRightLogical(a0.AsInt16(), 8); // hi byte
+                    Vector128<short> b1 = Sse2.ShiftRightLogical(a1.AsInt16(), 8);
+                    Vector128<short> b2 = Sse2.ShiftRightLogical(a2.AsInt16(), 8);
+                    Vector128<short> b3 = Sse2.ShiftRightLogical(a3.AsInt16(), 8);
+                    Vector128<byte> c0 = Sse2.And(a0, Mean16x4Mask); // lo byte
+                    Vector128<byte> c1 = Sse2.And(a1, Mean16x4Mask);
+                    Vector128<byte> c2 = Sse2.And(a2, Mean16x4Mask);
+                    Vector128<byte> c3 = Sse2.And(a3, Mean16x4Mask);
+                    Vector128<int> d0 = Sse2.Add(b0.AsInt32(), c0.AsInt32());
+                    Vector128<int> d1 = Sse2.Add(b1.AsInt32(), c1.AsInt32());
+                    Vector128<int> d2 = Sse2.Add(b2.AsInt32(), c2.AsInt32());
+                    Vector128<int> d3 = Sse2.Add(b3.AsInt32(), c3.AsInt32());
+                    Vector128<int> e0 = Sse2.Add(d0, d1);
+                    Vector128<int> e1 = Sse2.Add(d2, d3);
+                    Vector128<int> f0 = Sse2.Add(e0, e1);
+                    Sse2.Store(tmpPtr, f0.AsUInt16());
+                }
+#pragma warning restore SA1503 // Braces should not be omitted
+
+                dc[0] = (uint)(tmp[1] + tmp[0]);
+                dc[1] = (uint)(tmp[3] + tmp[2]);
+                dc[2] = (uint)(tmp[5] + tmp[4]);
+                dc[3] = (uint)(tmp[7] + tmp[6]);
+            }
+            else
+#endif
+            {
+                for (int k = 0; k < 4; k++)
+                {
+                    uint avg = 0;
+                    for (int y = 0; y < 4; y++)
                     {
-                        avg += input[x + (y * WebpConstants.Bps)];
+                        for (int x = 0; x < 4; x++)
+                        {
+                            avg += input[x + (y * WebpConstants.Bps)];
+                        }
                     }
-                }
 
-                dc[k] = avg;
-                input = input.Slice(4);   // go to next 4x4 block.
+                    dc[k] = avg;
+                    input = input.Slice(4); // go to next 4x4 block.
+                }
             }
         }