diff --git a/src/ImageSharp/Formats/Tiff/Compression/Decompressors/DeflateTiffCompression.cs b/src/ImageSharp/Formats/Tiff/Compression/Decompressors/DeflateTiffCompression.cs
index ef99832f70..bb57853d53 100644
--- a/src/ImageSharp/Formats/Tiff/Compression/Decompressors/DeflateTiffCompression.cs
+++ b/src/ImageSharp/Formats/Tiff/Compression/Decompressors/DeflateTiffCompression.cs
@@ -6,6 +6,7 @@ using System.IO.Compression;
 
 using SixLabors.ImageSharp.Compression.Zlib;
 using SixLabors.ImageSharp.Formats.Tiff.Constants;
+using SixLabors.ImageSharp.Formats.Tiff.PhotometricInterpretation;
 using SixLabors.ImageSharp.IO;
 using SixLabors.ImageSharp.Memory;
 
@@ -21,16 +22,23 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors
     {
         private readonly bool isBigEndian;
 
+        private readonly TiffColorType colorType;
+
         /// <summary>
         /// Initializes a new instance of the <see cref="DeflateTiffCompression" /> class.
         /// </summary>
         /// <param name="memoryAllocator">The memoryAllocator to use for buffer allocations.</param>
         /// <param name="width">The image width.</param>
         /// <param name="bitsPerPixel">The bits used per pixel.</param>
+        /// <param name="colorType">The color type of the pixel data.</param>
         /// <param name="predictor">The tiff predictor used.</param>
         /// <param name="isBigEndian">if set to <c>true</c> decodes the pixel data as big endian, otherwise as little endian.</param>
-        public DeflateTiffCompression(MemoryAllocator memoryAllocator, int width, int bitsPerPixel, TiffPredictor predictor, bool isBigEndian)
-            : base(memoryAllocator, width, bitsPerPixel, predictor) => this.isBigEndian = isBigEndian;
+        public DeflateTiffCompression(MemoryAllocator memoryAllocator, int width, int bitsPerPixel, TiffColorType colorType, TiffPredictor predictor, bool isBigEndian)
+            : base(memoryAllocator, width, bitsPerPixel, predictor)
+        {
+            this.colorType = colorType;
+            this.isBigEndian = isBigEndian;
+        }
 
         /// <inheritdoc/>
         protected override void Decompress(BufferedReadStream stream, int byteCount, Span<byte> buffer)
@@ -62,7 +70,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors
 
             if (this.Predictor == TiffPredictor.Horizontal)
             {
-                HorizontalPredictor.Undo(buffer, this.Width, this.BitsPerPixel, this.isBigEndian);
+                HorizontalPredictor.Undo(buffer, this.Width, this.colorType, this.isBigEndian);
             }
         }
 
diff --git a/src/ImageSharp/Formats/Tiff/Compression/Decompressors/LzwTiffCompression.cs b/src/ImageSharp/Formats/Tiff/Compression/Decompressors/LzwTiffCompression.cs
index 0fe1b60ecf..2e89396075 100644
--- a/src/ImageSharp/Formats/Tiff/Compression/Decompressors/LzwTiffCompression.cs
+++ b/src/ImageSharp/Formats/Tiff/Compression/Decompressors/LzwTiffCompression.cs
@@ -3,6 +3,7 @@
 
 using System;
 using SixLabors.ImageSharp.Formats.Tiff.Constants;
+using SixLabors.ImageSharp.Formats.Tiff.PhotometricInterpretation;
 using SixLabors.ImageSharp.IO;
 using SixLabors.ImageSharp.Memory;
 
@@ -15,16 +16,23 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors
     {
         private readonly bool isBigEndian;
 
+        private readonly TiffColorType colorType;
+
         /// <summary>
         /// Initializes a new instance of the <see cref="LzwTiffCompression" /> class.
         /// </summary>
         /// <param name="memoryAllocator">The memoryAllocator to use for buffer allocations.</param>
         /// <param name="width">The image width.</param>
         /// <param name="bitsPerPixel">The bits used per pixel.</param>
+        /// <param name="colorType">The color type of the pixel data.</param>
         /// <param name="predictor">The tiff predictor used.</param>
         /// <param name="isBigEndian">if set to <c>true</c> decodes the pixel data as big endian, otherwise as little endian.</param>
-        public LzwTiffCompression(MemoryAllocator memoryAllocator, int width, int bitsPerPixel, TiffPredictor predictor, bool isBigEndian)
-            : base(memoryAllocator, width, bitsPerPixel, predictor) => this.isBigEndian = isBigEndian;
+        public LzwTiffCompression(MemoryAllocator memoryAllocator, int width, int bitsPerPixel, TiffColorType colorType, TiffPredictor predictor, bool isBigEndian)
+            : base(memoryAllocator, width, bitsPerPixel, predictor)
+        {
+            this.colorType = colorType;
+            this.isBigEndian = isBigEndian;
+        }
 
         /// <inheritdoc/>
         protected override void Decompress(BufferedReadStream stream, int byteCount, Span<byte> buffer)
@@ -34,7 +42,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors
 
             if (this.Predictor == TiffPredictor.Horizontal)
             {
-                HorizontalPredictor.Undo(buffer, this.Width, this.BitsPerPixel, this.isBigEndian);
+                HorizontalPredictor.Undo(buffer, this.Width, this.colorType, this.isBigEndian);
             }
         }
 
diff --git a/src/ImageSharp/Formats/Tiff/Compression/HorizontalPredictor.cs b/src/ImageSharp/Formats/Tiff/Compression/HorizontalPredictor.cs
index da84b51b39..3685167d53 100644
--- a/src/ImageSharp/Formats/Tiff/Compression/HorizontalPredictor.cs
+++ b/src/ImageSharp/Formats/Tiff/Compression/HorizontalPredictor.cs
@@ -5,6 +5,7 @@ using System;
 using System.Buffers.Binary;
 using System.Runtime.CompilerServices;
 using System.Runtime.InteropServices;
+using SixLabors.ImageSharp.Formats.Tiff.PhotometricInterpretation;
 using SixLabors.ImageSharp.Formats.Tiff.Utils;
 using SixLabors.ImageSharp.PixelFormats;
 
@@ -20,21 +21,28 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
         /// </summary>
         /// <param name="pixelBytes">Buffer with decompressed pixel data.</param>
         /// <param name="width">The width of the image or strip.</param>
-        /// <param name="bitsPerPixel">Bits per pixel.</param>
+        /// <param name="colorType">The color type of the pixel data.</param>
         /// <param name="isBigEndian">if set to <c>true</c> decodes the pixel data as big endian, otherwise as little endian.</param>
-        public static void Undo(Span<byte> pixelBytes, int width, int bitsPerPixel, bool isBigEndian)
+        public static void Undo(Span<byte> pixelBytes, int width, TiffColorType colorType, bool isBigEndian)
         {
-            if (bitsPerPixel == 8)
-            {
-                Undo8Bit(pixelBytes, width);
-            }
-            else if (bitsPerPixel == 16)
+            switch (colorType)
             {
-                Undo16Bit(pixelBytes, width, isBigEndian);
-            }
-            else if (bitsPerPixel == 24)
-            {
-                Undo24Bit(pixelBytes, width);
+                case TiffColorType.BlackIsZero8:
+                case TiffColorType.WhiteIsZero8:
+                case TiffColorType.PaletteColor:
+                    UndoGray8Bit(pixelBytes, width);
+                    break;
+                case TiffColorType.BlackIsZero16:
+                case TiffColorType.WhiteIsZero16:
+                    UndoGray16Bit(pixelBytes, width, isBigEndian);
+                    break;
+                case TiffColorType.BlackIsZero32:
+                case TiffColorType.WhiteIsZero32:
+                    UndoGray32Bit(pixelBytes, width, isBigEndian);
+                    break;
+                case TiffColorType.Rgb888:
+                    UndoRgb24Bit(pixelBytes, width);
+                    break;
             }
         }
 
@@ -99,7 +107,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             }
         }
 
-        private static void Undo8Bit(Span<byte> pixelBytes, int width)
+        private static void UndoGray8Bit(Span<byte> pixelBytes, int width)
         {
             int rowBytesCount = width;
             int height = pixelBytes.Length / rowBytesCount;
@@ -116,7 +124,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             }
         }
 
-        private static void Undo16Bit(Span<byte> pixelBytes, int width, bool isBigEndian)
+        private static void UndoGray16Bit(Span<byte> pixelBytes, int width, bool isBigEndian)
         {
             int rowBytesCount = width * 2;
             int height = pixelBytes.Length / rowBytesCount;
@@ -160,7 +168,51 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             }
         }
 
-        private static void Undo24Bit(Span<byte> pixelBytes, int width)
+        private static void UndoGray32Bit(Span<byte> pixelBytes, int width, bool isBigEndian)
+        {
+            int rowBytesCount = width * 4;
+            int height = pixelBytes.Length / rowBytesCount;
+            if (isBigEndian)
+            {
+                for (int y = 0; y < height; y++)
+                {
+                    int offset = 0;
+                    Span<byte> rowBytes = pixelBytes.Slice(y * rowBytesCount, rowBytesCount);
+                    uint pixelValue = TiffUtils.ConvertToUIntBigEndian(rowBytes.Slice(offset, 4));
+                    offset += 4;
+
+                    for (int x = 1; x < width; x++)
+                    {
+                        Span<byte> rowSpan = rowBytes.Slice(offset, 4);
+                        uint diff = TiffUtils.ConvertToUIntBigEndian(rowSpan);
+                        pixelValue += diff;
+                        BinaryPrimitives.WriteUInt32BigEndian(rowSpan, pixelValue);
+                        offset += 4;
+                    }
+                }
+            }
+            else
+            {
+                for (int y = 0; y < height; y++)
+                {
+                    int offset = 0;
+                    Span<byte> rowBytes = pixelBytes.Slice(y * rowBytesCount, rowBytesCount);
+                    uint pixelValue = TiffUtils.ConvertToUIntLittleEndian(rowBytes.Slice(offset, 4));
+                    offset += 4;
+
+                    for (int x = 1; x < width; x++)
+                    {
+                        Span<byte> rowSpan = rowBytes.Slice(offset, 4);
+                        uint diff = TiffUtils.ConvertToUIntLittleEndian(rowSpan);
+                        pixelValue += diff;
+                        BinaryPrimitives.WriteUInt32LittleEndian(rowSpan, pixelValue);
+                        offset += 4;
+                    }
+                }
+            }
+        }
+
+        private static void UndoRgb24Bit(Span<byte> pixelBytes, int width)
         {
             int rowBytesCount = width * 3;
             int height = pixelBytes.Length / rowBytesCount;
diff --git a/src/ImageSharp/Formats/Tiff/Compression/TiffDecompressorsFactory.cs b/src/ImageSharp/Formats/Tiff/Compression/TiffDecompressorsFactory.cs
index 964f0bf127..083e53950a 100644
--- a/src/ImageSharp/Formats/Tiff/Compression/TiffDecompressorsFactory.cs
+++ b/src/ImageSharp/Formats/Tiff/Compression/TiffDecompressorsFactory.cs
@@ -3,6 +3,7 @@
 
 using SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors;
 using SixLabors.ImageSharp.Formats.Tiff.Constants;
+using SixLabors.ImageSharp.Formats.Tiff.PhotometricInterpretation;
 using SixLabors.ImageSharp.Memory;
 
 namespace SixLabors.ImageSharp.Formats.Tiff.Compression
@@ -15,6 +16,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             TiffPhotometricInterpretation photometricInterpretation,
             int width,
             int bitsPerPixel,
+            TiffColorType colorType,
             TiffPredictor predictor,
             FaxCompressionOptions faxOptions,
             ByteOrder byteOrder)
@@ -33,11 +35,11 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
 
                 case TiffDecoderCompressionType.Deflate:
                     DebugGuard.IsTrue(faxOptions == FaxCompressionOptions.None, "No fax compression options are expected");
-                    return new DeflateTiffCompression(allocator, width, bitsPerPixel, predictor, byteOrder == ByteOrder.BigEndian);
+                    return new DeflateTiffCompression(allocator, width, bitsPerPixel, colorType, predictor, byteOrder == ByteOrder.BigEndian);
 
                 case TiffDecoderCompressionType.Lzw:
                     DebugGuard.IsTrue(faxOptions == FaxCompressionOptions.None, "No fax compression options are expected");
-                    return new LzwTiffCompression(allocator, width, bitsPerPixel, predictor, byteOrder == ByteOrder.BigEndian);
+                    return new LzwTiffCompression(allocator, width, bitsPerPixel, colorType, predictor, byteOrder == ByteOrder.BigEndian);
 
                 case TiffDecoderCompressionType.T4:
                     DebugGuard.IsTrue(predictor == TiffPredictor.None, "Predictor should only be used with lzw or deflate compression");
diff --git a/src/ImageSharp/Formats/Tiff/PhotometricInterpretation/BlackIsZero32TiffColor{TPixel}.cs b/src/ImageSharp/Formats/Tiff/PhotometricInterpretation/BlackIsZero32TiffColor{TPixel}.cs
index 862756bc42..f54a794840 100644
--- a/src/ImageSharp/Formats/Tiff/PhotometricInterpretation/BlackIsZero32TiffColor{TPixel}.cs
+++ b/src/ImageSharp/Formats/Tiff/PhotometricInterpretation/BlackIsZero32TiffColor{TPixel}.cs
@@ -2,7 +2,6 @@
 // Licensed under the Apache License, Version 2.0.
 
 using System;
-using System.Numerics;
 using SixLabors.ImageSharp.Formats.Tiff.Utils;
 using SixLabors.ImageSharp.Memory;
 using SixLabors.ImageSharp.PixelFormats;
diff --git a/src/ImageSharp/Formats/Tiff/TiffDecoderCore.cs b/src/ImageSharp/Formats/Tiff/TiffDecoderCore.cs
index 2c7e8d0c8f..37bc01ad18 100644
--- a/src/ImageSharp/Formats/Tiff/TiffDecoderCore.cs
+++ b/src/ImageSharp/Formats/Tiff/TiffDecoderCore.cs
@@ -270,6 +270,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff
                     this.PhotometricInterpretation,
                     frame.Width,
                     bitsPerPixel,
+                    this.ColorType,
                     this.Predictor,
                     this.FaxCompressionOptions,
                     this.byteOrder);
@@ -321,6 +322,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff
                 this.PhotometricInterpretation,
                 frame.Width,
                 bitsPerPixel,
+                this.ColorType,
                 this.Predictor,
                 this.FaxCompressionOptions,
                 this.byteOrder);
diff --git a/tests/ImageSharp.Tests/Formats/Tiff/Compression/DeflateTiffCompressionTests.cs b/tests/ImageSharp.Tests/Formats/Tiff/Compression/DeflateTiffCompressionTests.cs
index e9399e23b5..c93a2018df 100644
--- a/tests/ImageSharp.Tests/Formats/Tiff/Compression/DeflateTiffCompressionTests.cs
+++ b/tests/ImageSharp.Tests/Formats/Tiff/Compression/DeflateTiffCompressionTests.cs
@@ -5,6 +5,7 @@ using System.IO;
 using SixLabors.ImageSharp.Compression.Zlib;
 using SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors;
 using SixLabors.ImageSharp.Formats.Tiff.Constants;
+using SixLabors.ImageSharp.Formats.Tiff.PhotometricInterpretation;
 using SixLabors.ImageSharp.IO;
 
 using Xunit;
@@ -26,7 +27,7 @@ namespace SixLabors.ImageSharp.Tests.Formats.Tiff.Compression
             {
                 var buffer = new byte[data.Length];
 
-                using var decompressor = new DeflateTiffCompression(Configuration.Default.MemoryAllocator, 10, 8, TiffPredictor.None, false);
+                using var decompressor = new DeflateTiffCompression(Configuration.Default.MemoryAllocator, 10, 8, TiffColorType.BlackIsZero8, TiffPredictor.None, false);
 
                 decompressor.Decompress(stream, 0, (uint)stream.Length, buffer);
 
diff --git a/tests/ImageSharp.Tests/Formats/Tiff/Compression/LzwTiffCompressionTests.cs b/tests/ImageSharp.Tests/Formats/Tiff/Compression/LzwTiffCompressionTests.cs
index 834d206cc7..5ea75d9a84 100644
--- a/tests/ImageSharp.Tests/Formats/Tiff/Compression/LzwTiffCompressionTests.cs
+++ b/tests/ImageSharp.Tests/Formats/Tiff/Compression/LzwTiffCompressionTests.cs
@@ -5,6 +5,7 @@ using System.IO;
 using SixLabors.ImageSharp.Formats.Tiff.Compression.Compressors;
 using SixLabors.ImageSharp.Formats.Tiff.Compression.Decompressors;
 using SixLabors.ImageSharp.Formats.Tiff.Constants;
+using SixLabors.ImageSharp.Formats.Tiff.PhotometricInterpretation;
 using SixLabors.ImageSharp.IO;
 using Xunit;
 
@@ -38,7 +39,7 @@ namespace SixLabors.ImageSharp.Tests.Formats.Tiff.Compression
             using BufferedReadStream stream = CreateCompressedStream(data);
             var buffer = new byte[data.Length];
 
-            using var decompressor = new LzwTiffCompression(Configuration.Default.MemoryAllocator, 10, 8, TiffPredictor.None, false);
+            using var decompressor = new LzwTiffCompression(Configuration.Default.MemoryAllocator, 10, 8, TiffColorType.BlackIsZero8, TiffPredictor.None, false);
             decompressor.Decompress(stream, 0, (uint)stream.Length, buffer);
 
             Assert.Equal(data, buffer);
diff --git a/tests/ImageSharp.Tests/Formats/Tiff/TiffDecoderTests.cs b/tests/ImageSharp.Tests/Formats/Tiff/TiffDecoderTests.cs
index bba27039dd..a8460e6c93 100644
--- a/tests/ImageSharp.Tests/Formats/Tiff/TiffDecoderTests.cs
+++ b/tests/ImageSharp.Tests/Formats/Tiff/TiffDecoderTests.cs
@@ -197,6 +197,17 @@ namespace SixLabors.ImageSharp.Tests.Formats.Tiff
             image.DebugSave(provider);
         }
 
+        [Theory]
+        [WithFile(Flower32BitGrayPredictorBigEndian, PixelTypes.Rgba32)]
+        [WithFile(Flower32BitGrayPredictorLittleEndian, PixelTypes.Rgba32)]
+        public void TiffDecoder_CanDecode_32Bit_Gray_WithPredictor<TPixel>(TestImageProvider<TPixel> provider)
+            where TPixel : unmanaged, IPixel<TPixel>
+        {
+            // Note: because the MagickReferenceDecoder fails to load the image, we only debug save them.
+            using Image<TPixel> image = provider.GetImage();
+            image.DebugSave(provider);
+        }
+
         [Theory]
         [WithFile(FlowerRgb121212Contiguous, PixelTypes.Rgba32)]
         public void TiffDecoder_CanDecode_36Bit<TPixel>(TestImageProvider<TPixel> provider)
diff --git a/tests/ImageSharp.Tests/TestImages.cs b/tests/ImageSharp.Tests/TestImages.cs
index 08b0b2901f..ff6c198c4d 100644
--- a/tests/ImageSharp.Tests/TestImages.cs
+++ b/tests/ImageSharp.Tests/TestImages.cs
@@ -607,6 +607,8 @@ namespace SixLabors.ImageSharp.Tests
             public const string Flower32BitGrayLittleEndian = "Tiff/flower-minisblack-32_lsb.tiff";
             public const string Flower32BitGrayMinIsWhite = "Tiff/flower-miniswhite-32.tiff";
             public const string Flower32BitGrayMinIsWhiteLittleEndian = "Tiff/flower-miniswhite-32_lsb.tiff";
+            public const string Flower32BitGrayPredictorBigEndian = "Tiff/flower-minisblack-32_msb_deflate_predictor.tiff";
+            public const string Flower32BitGrayPredictorLittleEndian = "Tiff/flower-minisblack-32_lsb_deflate_predictor.tiff";
 
             public const string Issues1716Rgb161616BitLittleEndian = "Tiff/Issues/Issue1716.tiff";
 
diff --git a/tests/Images/Input/Tiff/flower-minisblack-32_lsb_deflate_predictor.tiff b/tests/Images/Input/Tiff/flower-minisblack-32_lsb_deflate_predictor.tiff
new file mode 100644
index 0000000000..2dc9e8092a
--- /dev/null
+++ b/tests/Images/Input/Tiff/flower-minisblack-32_lsb_deflate_predictor.tiff
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:d5e7998cc985ef11ab9da410f18dcfb6b9a3169fb1ec01f9e61aa38d8ee4cfb6
+size 12704
diff --git a/tests/Images/Input/Tiff/flower-minisblack-32_msb_deflate_predictor.tiff b/tests/Images/Input/Tiff/flower-minisblack-32_msb_deflate_predictor.tiff
new file mode 100644
index 0000000000..f87c74c721
--- /dev/null
+++ b/tests/Images/Input/Tiff/flower-minisblack-32_msb_deflate_predictor.tiff
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:630e7f46655b6e61c4de7d56946a3a9225db68f776f9062ff2d5372547cc7c02
+size 12704