diff --git a/src/ImageSharp/Formats/Tiff/Compression/PackBitsWriter.cs b/src/ImageSharp/Formats/Tiff/Compression/PackBitsWriter.cs
index 389ad628e..1677976e4 100644
--- a/src/ImageSharp/Formats/Tiff/Compression/PackBitsWriter.cs
+++ b/src/ImageSharp/Formats/Tiff/Compression/PackBitsWriter.cs
@@ -10,7 +10,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
     /// </summary>
     internal static class PackBitsWriter
     {
-        public static int PackBits(Span<byte> rowSpan, Span<byte> compressedRowSpan)
+        public static int PackBits(ReadOnlySpan<byte> rowSpan, Span<byte> compressedRowSpan)
         {
             int maxRunLength = 127;
             int posInRowSpan = 0;
@@ -58,7 +58,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             return bytesWritten;
         }
 
-        private static void WriteLiteralRun(Span<byte> rowSpan, int end, int literalRunLength, Span<byte> compressedRowSpan, int compressedRowPos)
+        private static void WriteLiteralRun(ReadOnlySpan<byte> rowSpan, int end, int literalRunLength, Span<byte> compressedRowSpan, int compressedRowPos)
         {
             DebugGuard.MustBeLessThanOrEqualTo(literalRunLength, 127, nameof(literalRunLength));
 
@@ -68,7 +68,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             rowSpan.Slice(literalRunStart, literalRunLength).CopyTo(compressedRowSpan.Slice(compressedRowPos + 1));
         }
 
-        private static void WriteRun(Span<byte> rowSpan, int start, int runLength, Span<byte> compressedRowSpan, int compressedRowPos)
+        private static void WriteRun(ReadOnlySpan<byte> rowSpan, int start, int runLength, Span<byte> compressedRowSpan, int compressedRowPos)
         {
             DebugGuard.MustBeLessThanOrEqualTo(runLength, 127, nameof(runLength));
 
@@ -77,7 +77,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             compressedRowSpan[compressedRowPos + 1] = rowSpan[start];
         }
 
-        private static bool IsReplicateRun(Span<byte> rowSpan, int startPos)
+        private static bool IsReplicateRun(ReadOnlySpan<byte> rowSpan, int startPos)
         {
             // We consider run which has at least 3 same consecutive bytes a candidate for a run.
             var startByte = rowSpan[startPos];
@@ -101,7 +101,7 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Compression
             return false;
         }
 
-        private static int FindRunLength(Span<byte> rowSpan, int startPos, int maxRunLength)
+        private static int FindRunLength(ReadOnlySpan<byte> rowSpan, int startPos, int maxRunLength)
         {
             var startByte = rowSpan[startPos];
             int count = 1;
diff --git a/src/ImageSharp/Formats/Tiff/TiffEncoderCore.cs b/src/ImageSharp/Formats/Tiff/TiffEncoderCore.cs
index f3b138fbf..5e636c097 100644
--- a/src/ImageSharp/Formats/Tiff/TiffEncoderCore.cs
+++ b/src/ImageSharp/Formats/Tiff/TiffEncoderCore.cs
@@ -436,6 +436,11 @@ namespace SixLabors.ImageSharp.Formats.Tiff
                 return (ushort)TiffCompression.Deflate;
             }
 
+            if (this.CompressionType == TiffEncoderCompression.PackBits && this.Mode == TiffEncodingMode.ColorPalette)
+            {
+                return (ushort)TiffCompression.PackBits;
+            }
+
             if (this.CompressionType == TiffEncoderCompression.Deflate && this.Mode == TiffEncodingMode.BiColor)
             {
                 return (ushort)TiffCompression.Deflate;
diff --git a/src/ImageSharp/Formats/Tiff/Utils/TiffWriter.cs b/src/ImageSharp/Formats/Tiff/Utils/TiffWriter.cs
index 3060430ec..1cea6eaab 100644
--- a/src/ImageSharp/Formats/Tiff/Utils/TiffWriter.cs
+++ b/src/ImageSharp/Formats/Tiff/Utils/TiffWriter.cs
@@ -289,6 +289,11 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Utils
                 return this.WriteDeflateCompressedPalettedRgb(image, quantized, padding);
             }
 
+            if (compression == TiffEncoderCompression.PackBits)
+            {
+                return this.WritePackBitsCompressedPalettedRgb(image, quantized, padding);
+            }
+
             // No compression.
             int bytesWritten = 0;
             for (int y = 0; y < image.Height; y++)
@@ -341,6 +346,47 @@ namespace SixLabors.ImageSharp.Formats.Tiff.Utils
             return bytesWritten;
         }
 
+        /// <summary>
+        /// Writes the image data as indices into a color map compressed with deflate compression to the stream.
+        /// </summary>
+        /// <typeparam name="TPixel">The pixel data.</typeparam>
+        /// <param name="image">The image to write to the stream.</param>
+        /// <param name="quantized">The quantized frame.</param>
+        /// <param name="padding">The padding bytes for each row.</param>
+        /// <returns>The number of bytes written.</returns>
+        public int WritePackBitsCompressedPalettedRgb<TPixel>(Image<TPixel> image, IndexedImageFrame<TPixel> quantized, int padding)
+            where TPixel : unmanaged, IPixel<TPixel>
+        {
+            // Worst case is that the actual compressed data is larger then the input data. In this case we need 1 additional byte per 127 bytes.
+            int additionalBytes = (image.Width * 3 / 127) + 1;
+            using IManagedByteBuffer compressedRow = this.memoryAllocator.AllocateManagedByteBuffer((image.Width * 3) + additionalBytes, AllocationOptions.Clean);
+            using IManagedByteBuffer pixelRowWithPadding = this.memoryAllocator.AllocateManagedByteBuffer((image.Width * 3) + padding, AllocationOptions.Clean);
+            Span<byte> compressedRowSpan = compressedRow.GetSpan();
+            Span<byte> pixelRowWithPaddingSpan = pixelRowWithPadding.GetSpan();
+
+            int bytesWritten = 0;
+            for (int y = 0; y < image.Height; y++)
+            {
+                ReadOnlySpan<byte> pixelSpan = quantized.GetPixelRowSpan(y);
+
+                int size = 0;
+                if (padding != 0)
+                {
+                    pixelSpan.CopyTo(pixelRowWithPaddingSpan);
+                    size = PackBitsWriter.PackBits(pixelRowWithPaddingSpan, compressedRowSpan);
+                }
+                else
+                {
+                    size = PackBitsWriter.PackBits(pixelSpan, compressedRowSpan);
+                }
+
+                this.output.Write(compressedRowSpan.Slice(0, size));
+                bytesWritten += size;
+            }
+
+            return bytesWritten;
+        }
+
         /// <summary>
         /// Writes the image data as 8 bit gray to the stream.
         /// </summary>
diff --git a/tests/ImageSharp.Tests/Formats/Tiff/TiffEncoderTests.cs b/tests/ImageSharp.Tests/Formats/Tiff/TiffEncoderTests.cs
index 294a9c0cf..34b713d6e 100644
--- a/tests/ImageSharp.Tests/Formats/Tiff/TiffEncoderTests.cs
+++ b/tests/ImageSharp.Tests/Formats/Tiff/TiffEncoderTests.cs
@@ -88,6 +88,12 @@ namespace SixLabors.ImageSharp.Tests.Formats.Tiff
         public void TiffEncoder_EncodeColorPalette_WithDeflateCompression_Works<TPixel>(TestImageProvider<TPixel> provider)
             where TPixel : unmanaged, IPixel<TPixel> => TestTiffEncoderCore(provider, TiffBitsPerPixel.Pixel24, TiffEncodingMode.ColorPalette, TiffEncoderCompression.Deflate);
 
+        // TODO: this test fails, but the output looks correct. I thinks its due to the fact that a quantizer is used to create the palette.
+        [Theory]
+        [WithFile(TestImages.Tiff.Calliphora_PaletteUncompressed, PixelTypes.Rgba32)]
+        public void TiffEncoder_EncodeColorPalette_WithPackBitsCompression_Works<TPixel>(TestImageProvider<TPixel> provider)
+            where TPixel : unmanaged, IPixel<TPixel> => TestTiffEncoderCore(provider, TiffBitsPerPixel.Pixel24, TiffEncodingMode.ColorPalette, TiffEncoderCompression.PackBits);
+
         [Theory]
         [WithFile(TestImages.Tiff.Calliphora_BiColor, PixelTypes.Rgba32)]
         public void TiffEncoder_EncodeBiColor_Works<TPixel>(TestImageProvider<TPixel> provider)