diff --git a/src/ImageSharp/Formats/Webp/Lossy/LossyUtils.cs b/src/ImageSharp/Formats/Webp/Lossy/LossyUtils.cs
index d5db3dffa5..82e2214701 100644
--- a/src/ImageSharp/Formats/Webp/Lossy/LossyUtils.cs
+++ b/src/ImageSharp/Formats/Webp/Lossy/LossyUtils.cs
@@ -4,11 +4,16 @@
 using System;
 using System.Buffers.Binary;
 using System.Runtime.CompilerServices;
+#if SUPPORTS_RUNTIME_INTRINSICS
+using System.Numerics;
+using System.Runtime.Intrinsics;
+using System.Runtime.Intrinsics.X86;
+#endif
 
 // ReSharper disable InconsistentNaming
 namespace SixLabors.ImageSharp.Formats.Webp.Lossy
 {
-    internal static class LossyUtils
+    internal static unsafe class LossyUtils
     {
         [MethodImpl(InliningOptions.ShortMethod)]
         public static int Vp8Sse16X16(Span<byte> a, Span<byte> b) => GetSse(a, b, 16, 16);
@@ -17,7 +22,57 @@ namespace SixLabors.ImageSharp.Formats.Webp.Lossy
         public static int Vp8Sse16X8(Span<byte> a, Span<byte> b) => GetSse(a, b, 16, 8);
 
         [MethodImpl(InliningOptions.ShortMethod)]
-        public static int Vp8Sse4X4(Span<byte> a, Span<byte> b) => GetSse(a, b, 4, 4);
+        public static int Vp8Sse4X4(Span<byte> a, Span<byte> b)
+        {
+#if SUPPORTS_RUNTIME_INTRINSICS
+            if (Sse2.IsSupported)
+            {
+#pragma warning disable SA1503 // Braces should not be omitted
+                Span<int> tmp = stackalloc int[4];
+                fixed (byte* aPtr = a)
+                fixed (byte* bPtr = b)
+                fixed (int* tmpPtr = tmp)
+                {
+                    // Load values.
+                    Vector128<byte> a0 = Sse2.LoadVector128(aPtr);
+                    Vector128<byte> a1 = Sse2.LoadVector128(aPtr + WebpConstants.Bps);
+                    Vector128<byte> a2 = Sse2.LoadVector128(aPtr + (WebpConstants.Bps * 2));
+                    Vector128<byte> a3 = Sse2.LoadVector128(aPtr + (WebpConstants.Bps * 3));
+                    Vector128<byte> b0 = Sse2.LoadVector128(bPtr);
+                    Vector128<byte> b1 = Sse2.LoadVector128(bPtr + WebpConstants.Bps);
+                    Vector128<byte> b2 = Sse2.LoadVector128(bPtr + (WebpConstants.Bps * 2));
+                    Vector128<byte> b3 = Sse2.LoadVector128(bPtr + (WebpConstants.Bps * 3));
+
+                    // Combine pair of lines.
+                    Vector128<int> a01 = Sse2.UnpackLow(a0.AsInt32(), a1.AsInt32());
+                    Vector128<int> a23 = Sse2.UnpackLow(a2.AsInt32(), a3.AsInt32());
+                    Vector128<int> b01 = Sse2.UnpackLow(b0.AsInt32(), b1.AsInt32());
+                    Vector128<int> b23 = Sse2.UnpackLow(b2.AsInt32(), b3.AsInt32());
+
+                    // Convert to 16b.
+                    Vector128<byte> a01s = Sse2.UnpackLow(a01.AsByte(), Vector128<byte>.Zero);
+                    Vector128<byte> a23s = Sse2.UnpackLow(a23.AsByte(), Vector128<byte>.Zero);
+                    Vector128<byte> b01s = Sse2.UnpackLow(b01.AsByte(), Vector128<byte>.Zero);
+                    Vector128<byte> b23s = Sse2.UnpackLow(b23.AsByte(), Vector128<byte>.Zero);
+
+                    // subtract, square and accumulate.
+                    Vector128<byte> d0 = Sse2.SubtractSaturate(a01s, b01s);
+                    Vector128<byte> d1 = Sse2.SubtractSaturate(a23s, b23s);
+                    Vector128<int> e0 = Sse2.MultiplyAddAdjacent(d0.AsInt16(), d0.AsInt16());
+                    Vector128<int> e1 = Sse2.MultiplyAddAdjacent(d1.AsInt16(), d1.AsInt16());
+                    Vector128<int> sum = Sse2.Add(e0, e1);
+
+                    Sse2.Store(tmpPtr, sum);
+                    return tmp[3] + tmp[2] + tmp[1] + tmp[0];
+                }
+#pragma warning restore SA1503 // Braces should not be omitted
+            }
+            else
+#endif
+            {
+                return GetSse(a, b, 4, 4);
+            }
+        }
 
         [MethodImpl(InliningOptions.ShortMethod)]
         public static int GetSse(Span<byte> a, Span<byte> b, int w, int h)