diff --git a/Directory.Build.props b/Directory.Build.props
index 3a133efe7..3df93fcd4 100644
--- a/Directory.Build.props
+++ b/Directory.Build.props
@@ -18,4 +18,13 @@
   <!-- Import the shared global .props file -->
   <Import Project="$(MSBuildThisFileDirectory)shared-infrastructure\msbuild\props\SixLabors.Global.props" />
 
+  <!-- Custom Project Configuration doesn't seem to copy this setting properly. -->
+  <PropertyGroup Condition="$(Configuration.StartsWith('Debug')) == true">
+    <Optimize>false</Optimize>
+  </PropertyGroup>
+
+  <PropertyGroup Condition="$(Configuration.StartsWith('Release')) == true">
+    <Optimize>true</Optimize>
+  </PropertyGroup>
+  
 </Project>
diff --git a/ImageSharp.sln b/ImageSharp.sln
index 8dfab6033..83208994c 100644
--- a/ImageSharp.sln
+++ b/ImageSharp.sln
@@ -482,9 +482,15 @@ Global
 		Debug|Any CPU = Debug|Any CPU
 		Debug|x64 = Debug|x64
 		Debug|x86 = Debug|x86
+		Debug-InnerLoop|Any CPU = Debug-InnerLoop|Any CPU
+		Debug-InnerLoop|x64 = Debug-InnerLoop|x64
+		Debug-InnerLoop|x86 = Debug-InnerLoop|x86
 		Release|Any CPU = Release|Any CPU
 		Release|x64 = Release|x64
 		Release|x86 = Release|x86
+		Release-InnerLoop|Any CPU = Release-InnerLoop|Any CPU
+		Release-InnerLoop|x64 = Release-InnerLoop|x64
+		Release-InnerLoop|x86 = Release-InnerLoop|x86
 	EndGlobalSection
 	GlobalSection(ProjectConfigurationPlatforms) = postSolution
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
@@ -493,48 +499,96 @@ Global
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug|x64.Build.0 = Debug|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug|x86.ActiveCfg = Debug|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug|x86.Build.0 = Debug|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug-InnerLoop|Any CPU.ActiveCfg = Debug-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug-InnerLoop|Any CPU.Build.0 = Debug-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug-InnerLoop|x64.ActiveCfg = Debug-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug-InnerLoop|x64.Build.0 = Debug-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug-InnerLoop|x86.ActiveCfg = Debug-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Debug-InnerLoop|x86.Build.0 = Debug-InnerLoop|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release|Any CPU.ActiveCfg = Release|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release|Any CPU.Build.0 = Release|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release|x64.ActiveCfg = Release|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release|x64.Build.0 = Release|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release|x86.ActiveCfg = Release|Any CPU
 		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release|x86.Build.0 = Release|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release-InnerLoop|Any CPU.ActiveCfg = Release-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release-InnerLoop|Any CPU.Build.0 = Release-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release-InnerLoop|x64.ActiveCfg = Release-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release-InnerLoop|x64.Build.0 = Release-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release-InnerLoop|x86.ActiveCfg = Release-InnerLoop|Any CPU
+		{2AA31A1F-142C-43F4-8687-09ABCA4B3A26}.Release-InnerLoop|x86.Build.0 = Release-InnerLoop|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug|Any CPU.Build.0 = Debug|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug|x64.ActiveCfg = Debug|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug|x64.Build.0 = Debug|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug|x86.ActiveCfg = Debug|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug|x86.Build.0 = Debug|Any CPU
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug-InnerLoop|Any CPU.ActiveCfg = Debug-InnerLoop|Any CPU
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug-InnerLoop|Any CPU.Build.0 = Debug-InnerLoop|Any CPU
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug-InnerLoop|x64.ActiveCfg = Debug-InnerLoop|x64
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug-InnerLoop|x64.Build.0 = Debug-InnerLoop|x64
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug-InnerLoop|x86.ActiveCfg = Debug-InnerLoop|x86
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Debug-InnerLoop|x86.Build.0 = Debug-InnerLoop|x86
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release|Any CPU.ActiveCfg = Release|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release|Any CPU.Build.0 = Release|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release|x64.ActiveCfg = Release|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release|x64.Build.0 = Release|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release|x86.ActiveCfg = Release|Any CPU
 		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release|x86.Build.0 = Release|Any CPU
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release-InnerLoop|Any CPU.ActiveCfg = Release-InnerLoop|Any CPU
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release-InnerLoop|Any CPU.Build.0 = Release-InnerLoop|Any CPU
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release-InnerLoop|x64.ActiveCfg = Release-InnerLoop|x64
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release-InnerLoop|x64.Build.0 = Release-InnerLoop|x64
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release-InnerLoop|x86.ActiveCfg = Release-InnerLoop|x86
+		{EA3000E9-2A91-4EC4-8A68-E566DEBDC4F6}.Release-InnerLoop|x86.Build.0 = Release-InnerLoop|x86
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug|Any CPU.Build.0 = Debug|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug|x64.ActiveCfg = Debug|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug|x64.Build.0 = Debug|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug|x86.ActiveCfg = Debug|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug|x86.Build.0 = Debug|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug-InnerLoop|Any CPU.ActiveCfg = Debug-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug-InnerLoop|Any CPU.Build.0 = Debug-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug-InnerLoop|x64.ActiveCfg = Debug-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug-InnerLoop|x64.Build.0 = Debug-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug-InnerLoop|x86.ActiveCfg = Debug-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Debug-InnerLoop|x86.Build.0 = Debug-InnerLoop|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release|Any CPU.ActiveCfg = Release|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release|Any CPU.Build.0 = Release|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release|x64.ActiveCfg = Release|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release|x64.Build.0 = Release|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release|x86.ActiveCfg = Release|Any CPU
 		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release|x86.Build.0 = Release|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release-InnerLoop|Any CPU.ActiveCfg = Release-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release-InnerLoop|Any CPU.Build.0 = Release-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release-InnerLoop|x64.ActiveCfg = Release-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release-InnerLoop|x64.Build.0 = Release-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release-InnerLoop|x86.ActiveCfg = Release-InnerLoop|Any CPU
+		{2BF743D8-2A06-412D-96D7-F448F00C5EA5}.Release-InnerLoop|x86.Build.0 = Release-InnerLoop|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug|Any CPU.Build.0 = Debug|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug|x64.ActiveCfg = Debug|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug|x64.Build.0 = Debug|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug|x86.ActiveCfg = Debug|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug|x86.Build.0 = Debug|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug-InnerLoop|Any CPU.ActiveCfg = Debug-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug-InnerLoop|Any CPU.Build.0 = Debug-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug-InnerLoop|x64.ActiveCfg = Debug-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug-InnerLoop|x64.Build.0 = Debug-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug-InnerLoop|x86.ActiveCfg = Debug-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Debug-InnerLoop|x86.Build.0 = Debug-InnerLoop|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Release|Any CPU.ActiveCfg = Release|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Release|Any CPU.Build.0 = Release|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Release|x64.ActiveCfg = Release|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Release|x64.Build.0 = Release|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Release|x86.ActiveCfg = Release|Any CPU
 		{FC527290-2F22-432C-B77B-6E815726B02C}.Release|x86.Build.0 = Release|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Release-InnerLoop|Any CPU.ActiveCfg = Release-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Release-InnerLoop|Any CPU.Build.0 = Release-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Release-InnerLoop|x64.ActiveCfg = Release-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Release-InnerLoop|x64.Build.0 = Release-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Release-InnerLoop|x86.ActiveCfg = Release-InnerLoop|Any CPU
+		{FC527290-2F22-432C-B77B-6E815726B02C}.Release-InnerLoop|x86.Build.0 = Release-InnerLoop|Any CPU
 	EndGlobalSection
 	GlobalSection(SolutionProperties) = preSolution
 		HideSolutionNode = FALSE
diff --git a/src/ImageSharp/ImageSharp.csproj b/src/ImageSharp/ImageSharp.csproj
index 832d551fd..510f34dc7 100644
--- a/src/ImageSharp/ImageSharp.csproj
+++ b/src/ImageSharp/ImageSharp.csproj
@@ -12,6 +12,7 @@
     <PackageProjectUrl>$(RepositoryUrl)</PackageProjectUrl>
     <PackageTags>Image Resize Crop Gif Jpg Jpeg Bitmap Png Tga NetCore</PackageTags>
     <Description>A new, fully featured, fully managed, cross-platform, 2D graphics API for .NET</Description>
+    <Configurations>Debug;Release;Release-InnerLoop;Debug-InnerLoop</Configurations>
   </PropertyGroup>
 
   <Choose>
@@ -20,6 +21,11 @@
         <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;netstandard2.1;netstandard2.0;netstandard1.3;net472</TargetFrameworks>
       </PropertyGroup>
     </When>
+    <When Condition="$(Configuration.EndsWith('InnerLoop')) == true">
+      <PropertyGroup>
+        <TargetFrameworks>netcoreapp3.1</TargetFrameworks>
+      </PropertyGroup>
+    </When>
     <Otherwise>
       <PropertyGroup>
         <TargetFrameworks>netcoreapp3.1;netcoreapp2.1;netstandard2.1;netstandard2.0;netstandard1.3;net472</TargetFrameworks>
diff --git a/tests/ImageSharp.Benchmarks/ImageSharp.Benchmarks.csproj b/tests/ImageSharp.Benchmarks/ImageSharp.Benchmarks.csproj
index d89cf79fc..a146dc03e 100644
--- a/tests/ImageSharp.Benchmarks/ImageSharp.Benchmarks.csproj
+++ b/tests/ImageSharp.Benchmarks/ImageSharp.Benchmarks.csproj
@@ -5,15 +5,28 @@
     <AssemblyName>ImageSharp.Benchmarks</AssemblyName>
     <OutputType>Exe</OutputType>
     <RootNamespace>SixLabors.ImageSharp.Benchmarks</RootNamespace>
-    <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;net472</TargetFrameworks>
     <GenerateProgramFile>false</GenerateProgramFile>
     <!--Used to hide test project from dotnet test-->
     <IsTestProject>false</IsTestProject>
+    <Configurations>Debug;Release;Release-InnerLoop;Debug-InnerLoop</Configurations>
 
     <!-- Uncomment this to run benchmarks depending on Colorful or Pfim (colorspaces and TGA): -->
     <!--<SignAssembly>false</SignAssembly>-->
   </PropertyGroup>
 
+  <Choose>
+    <When Condition="$(Configuration.EndsWith('InnerLoop')) == true">
+      <PropertyGroup>
+        <TargetFrameworks>netcoreapp3.1</TargetFrameworks>
+      </PropertyGroup>
+    </When>
+    <Otherwise>
+      <PropertyGroup>
+        <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;net472</TargetFrameworks>
+      </PropertyGroup>
+    </Otherwise>
+  </Choose>
+
   <ItemGroup>
     <Compile Include="..\ImageSharp.Tests\TestImages.cs" Link="Tests\TestImages.cs" />
     <Compile Include="..\ImageSharp.Tests\TestUtilities\TestEnvironment.cs" Link="Tests\TestEnvironment.cs" />
diff --git a/tests/ImageSharp.Tests.ProfilingSandbox/ImageSharp.Tests.ProfilingSandbox.csproj b/tests/ImageSharp.Tests.ProfilingSandbox/ImageSharp.Tests.ProfilingSandbox.csproj
index 220780c58..915947532 100644
--- a/tests/ImageSharp.Tests.ProfilingSandbox/ImageSharp.Tests.ProfilingSandbox.csproj
+++ b/tests/ImageSharp.Tests.ProfilingSandbox/ImageSharp.Tests.ProfilingSandbox.csproj
@@ -8,13 +8,26 @@
     <Prefer32Bit>false</Prefer32Bit>
     <RootNamespace>SixLabors.ImageSharp.Tests.ProfilingSandbox</RootNamespace>
     <RuntimeIdentifier>win7-x64</RuntimeIdentifier>
-    <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;net472</TargetFrameworks>
     <StartupObject>SixLabors.ImageSharp.Tests.ProfilingSandbox.Program</StartupObject>
     <!--Used to hide test project from dotnet test-->
     <IsTestProject>false</IsTestProject>
     <EnsureNETCoreAppRuntime>false</EnsureNETCoreAppRuntime>
+    <Configurations>Debug;Release;Release-InnerLoop;Debug-InnerLoop</Configurations>
   </PropertyGroup>
 
+  <Choose>
+    <When Condition="$(Configuration.EndsWith('InnerLoop')) == true">
+      <PropertyGroup>
+        <TargetFrameworks>netcoreapp3.1</TargetFrameworks>
+      </PropertyGroup>
+    </When>
+    <Otherwise>
+      <PropertyGroup>
+        <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;net472</TargetFrameworks>
+      </PropertyGroup>
+    </Otherwise>
+  </Choose>
+
   <ItemGroup>
     <Compile Remove="..\ImageSharp.Tests\IO\LocalFileSystem.cs" />
   </ItemGroup>
diff --git a/tests/ImageSharp.Tests.ProfilingSandbox/app.config b/tests/ImageSharp.Tests.ProfilingSandbox/app.config
index 3328297a5..a74fa1315 100644
--- a/tests/ImageSharp.Tests.ProfilingSandbox/app.config
+++ b/tests/ImageSharp.Tests.ProfilingSandbox/app.config
@@ -1,4 +1,4 @@
-<?xml version="1.0" encoding="utf-8"?>
+<?xml version="1.0" encoding="utf-8"?>
 <configuration>
   <runtime>
     <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
@@ -12,8 +12,8 @@
       </dependentAssembly>
       <dependentAssembly>
         <assemblyIdentity name="System.Runtime.CompilerServices.Unsafe" publicKeyToken="b03f5f7f11d50a3a" culture="neutral" />
-        <bindingRedirect oldVersion="0.0.0.0-4.0.2.0" newVersion="4.0.2.0" />
+        <bindingRedirect oldVersion="0.0.0.0-5.0.0.0" newVersion="5.0.0.0" />
       </dependentAssembly>
     </assemblyBinding>
   </runtime>
-</configuration>
\ No newline at end of file
+</configuration>
diff --git a/tests/ImageSharp.Tests/ImageSharp.Tests.csproj b/tests/ImageSharp.Tests/ImageSharp.Tests.csproj
index ebbe2cbdf..b6482455e 100644
--- a/tests/ImageSharp.Tests/ImageSharp.Tests.csproj
+++ b/tests/ImageSharp.Tests/ImageSharp.Tests.csproj
@@ -2,13 +2,26 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;net472</TargetFrameworks>
     <DebugSymbols>True</DebugSymbols>
     <AssemblyName>SixLabors.ImageSharp.Tests</AssemblyName>
     <Platforms>AnyCPU;x64;x86</Platforms>
     <RootNamespace>SixLabors.ImageSharp.Tests</RootNamespace>
+    <Configurations>Debug;Release;Release-InnerLoop;Debug-InnerLoop</Configurations>
   </PropertyGroup>
 
+  <Choose>
+    <When Condition="$(Configuration.EndsWith('InnerLoop')) == true">
+      <PropertyGroup>
+        <TargetFrameworks>netcoreapp3.1</TargetFrameworks>
+      </PropertyGroup>
+    </When>
+    <Otherwise>
+      <PropertyGroup>
+        <TargetFrameworks>net5.0;netcoreapp3.1;netcoreapp2.1;net472</TargetFrameworks>
+      </PropertyGroup>
+    </Otherwise>
+  </Choose>
+  
   <ItemGroup>
     <InternalsVisibleTo Include="ImageSharp.Tests.ProfilingSandbox" Key="$(SixLaborsPublicKey)" />
   </ItemGroup>