diff --git a/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/AwsBlobProviderConfiguration.cs b/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/AwsBlobProviderConfiguration.cs
index 77919b80ef..e5a8a853d7 100644
--- a/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/AwsBlobProviderConfiguration.cs
+++ b/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/AwsBlobProviderConfiguration.cs
@@ -57,9 +57,9 @@ public class AwsBlobProviderConfiguration
         set => _containerConfiguration.SetConfiguration(AwsBlobProviderConfigurationNames.Policy, value);
     }
 
-    public string Region {
-        get => _containerConfiguration.GetConfiguration<string>(AwsBlobProviderConfigurationNames.Region);
-        set => _containerConfiguration.SetConfiguration(AwsBlobProviderConfigurationNames.Region, Check.NotNull(value, nameof(value)));
+    public string? Region {
+        get => _containerConfiguration.GetConfigurationOrDefault<string>(AwsBlobProviderConfigurationNames.Region);
+        set => _containerConfiguration.SetConfiguration(AwsBlobProviderConfigurationNames.Region, value);
     }
 
     /// <summary>
diff --git a/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory.cs b/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory.cs
index dc2a7fe56b..1572adca7c 100644
--- a/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory.cs
+++ b/framework/src/Volo.Abp.BlobStoring.Aws/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory.cs
@@ -30,7 +30,9 @@ public class DefaultAmazonS3ClientFactory : IAmazonS3ClientFactory, ITransientDe
     public virtual async Task<AmazonS3Client> GetAmazonS3Client(
         AwsBlobProviderConfiguration configuration)
     {
-        var region = RegionEndpoint.GetBySystemName(configuration.Region);
+        var region = !configuration.Region.IsNullOrWhiteSpace() 
+            ? RegionEndpoint.GetBySystemName(configuration.Region)
+            : null;
         var clientConfig = CreateS3ClientConfig(configuration, region);
 
         if (configuration.UseCredentials)
@@ -58,12 +60,15 @@ public class DefaultAmazonS3ClientFactory : IAmazonS3ClientFactory, ITransientDe
         return new AmazonS3Client(configuration.AccessKeyId, configuration.SecretAccessKey, clientConfig);
     }
 
-    protected virtual AmazonS3Config CreateS3ClientConfig(AwsBlobProviderConfiguration configuration, RegionEndpoint region)
+    protected virtual AmazonS3Config CreateS3ClientConfig(AwsBlobProviderConfiguration configuration, RegionEndpoint? region)
     {
-        var clientConfig = new AmazonS3Config
+        var clientConfig = new AmazonS3Config();
+
+        // Set region only if it's provided (for AWS S3)
+        if (region != null)
         {
-            RegionEndpoint = region
-        };
+            clientConfig.RegionEndpoint = region;
+        }
 
         if (!configuration.ServiceURL.IsNullOrWhiteSpace())
         {
diff --git a/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/AbpBlobStoringAwsTestModule.cs b/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/AbpBlobStoringAwsTestModule.cs
index 6edd0fc669..984a66bbc1 100644
--- a/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/AbpBlobStoringAwsTestModule.cs
+++ b/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/AbpBlobStoringAwsTestModule.cs
@@ -69,23 +69,39 @@ public class AbpBlobStoringAwsTestModule : AbpModule
 
     private async Task DeleteBucketAsync(ApplicationShutdownContext context)
     {
-        var amazonS3Client = await context.ServiceProvider.GetRequiredService<IAmazonS3ClientFactory>()
-            .GetAmazonS3Client(_configuration);
+        // Skip bucket deletion if configuration is not properly set (e.g., in unit tests)
+        if (_configuration == null || 
+            string.IsNullOrWhiteSpace(_configuration.AccessKeyId) || 
+            string.IsNullOrWhiteSpace(_configuration.SecretAccessKey) ||
+            (string.IsNullOrWhiteSpace(_configuration.Region) && string.IsNullOrWhiteSpace(_configuration.ServiceURL)))
+        {
+            return;
+        }
 
-        if (await AmazonS3Util.DoesS3BucketExistV2Async(amazonS3Client, _randomContainerName))
+        try
         {
-            var blobs = await amazonS3Client.ListObjectsAsync(_randomContainerName);
+            var amazonS3Client = await context.ServiceProvider.GetRequiredService<IAmazonS3ClientFactory>()
+                .GetAmazonS3Client(_configuration);
 
-            if (blobs.S3Objects.Any())
+            if (await AmazonS3Util.DoesS3BucketExistV2Async(amazonS3Client, _randomContainerName))
             {
-                await amazonS3Client.DeleteObjectsAsync(new DeleteObjectsRequest
+                var blobs = await amazonS3Client.ListObjectsAsync(_randomContainerName);
+
+                if (blobs.S3Objects.Any())
                 {
-                    BucketName = _randomContainerName,
-                    Objects = blobs.S3Objects.Select(o => new KeyVersion { Key = o.Key }).ToList()
-                });
-            }
+                    await amazonS3Client.DeleteObjectsAsync(new DeleteObjectsRequest
+                    {
+                        BucketName = _randomContainerName,
+                        Objects = blobs.S3Objects.Select(o => new KeyVersion { Key = o.Key }).ToList()
+                    });
+                }
 
-            await amazonS3Client.DeleteBucketAsync(_randomContainerName);
+                await amazonS3Client.DeleteBucketAsync(_randomContainerName);
+            }
+        }
+        catch
+        {
+            // Ignore errors during test cleanup
         }
     }
 }
diff --git a/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory_Tests.cs b/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory_Tests.cs
index cf5b973ee0..5f7539de9e 100644
--- a/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory_Tests.cs
+++ b/framework/test/Volo.Abp.BlobStoring.Aws.Tests/Volo/Abp/BlobStoring/Aws/DefaultAmazonS3ClientFactory_Tests.cs
@@ -61,4 +61,27 @@ public class DefaultAmazonS3ClientFactory_Tests : AbpBlobStoringAwsTestBase
         s3Client.Config.ServiceURL.ShouldBeNull(); // Should use default AWS S3 service
         ((AmazonS3Config)s3Client.Config).ForcePathStyle.ShouldBeFalse(); // Should be false for AWS S3
     }
+
+    [Fact]
+    public async Task Should_Create_S3Client_Without_Region_For_S3Compatible_Services()
+    {
+        // Arrange
+        var containerConfiguration = new BlobContainerConfiguration();
+        
+        var awsConfiguration = new AwsBlobProviderConfiguration(containerConfiguration)
+        {
+            AccessKeyId = "test-access-key",
+            SecretAccessKey = "test-secret-key",
+            ServiceURL = "https://minio.example.com:9000"
+            // Region not set - should work for S3-compatible services
+        };
+
+        // Act
+        using var s3Client = await _amazonS3ClientFactory.GetAmazonS3Client(awsConfiguration);
+
+        // Assert
+        s3Client.ShouldNotBeNull();
+        s3Client.Config.ServiceURL.ShouldBe("https://minio.example.com:9000/"); // AWS SDK automatically appends trailing slash
+        ((AmazonS3Config)s3Client.Config).ForcePathStyle.ShouldBeTrue(); // Should be enabled for S3-compatible services
+    }
 } 
\ No newline at end of file