diff --git a/framework/src/Volo.Abp.AspNetCore.Mvc.Client/Volo/Abp/AspNetCore/Mvc/Client/MvcCachedApplicationConfigurationClient.cs b/framework/src/Volo.Abp.AspNetCore.Mvc.Client/Volo/Abp/AspNetCore/Mvc/Client/MvcCachedApplicationConfigurationClient.cs
index 5d87371ae8..8478cc49cb 100644
--- a/framework/src/Volo.Abp.AspNetCore.Mvc.Client/Volo/Abp/AspNetCore/Mvc/Client/MvcCachedApplicationConfigurationClient.cs
+++ b/framework/src/Volo.Abp.AspNetCore.Mvc.Client/Volo/Abp/AspNetCore/Mvc/Client/MvcCachedApplicationConfigurationClient.cs
@@ -16,7 +16,7 @@ namespace Volo.Abp.AspNetCore.Mvc.Client;
 
 public class MvcCachedApplicationConfigurationClient : ICachedApplicationConfigurationClient, ITransientDependency
 {
-    private const string ApplicationConfigurationDtoCacheKey = "ApplicationConfigurationDto_CacheKey";
+    private const string HttpContextItemsCacheKeyFormat = "ApplicationConfigurationDto_{0}_{1}_CacheKey";
 
     protected IHttpContextAccessor HttpContextAccessor { get; }
     protected AbpApplicationConfigurationClientProxy ApplicationConfigurationAppService { get; }
@@ -48,7 +48,8 @@ public class MvcCachedApplicationConfigurationClient : ICachedApplicationConfigu
     {
         string? cacheKey = null;
         var httpContext = HttpContextAccessor?.HttpContext;
-        if (httpContext != null && httpContext.Items[ApplicationConfigurationDtoCacheKey] is string key)
+        var itemsKey = GetHttpContextItemsCacheKey();
+        if (httpContext != null && httpContext.Items[itemsKey] is string key)
         {
             cacheKey = key;
         }
@@ -58,7 +59,7 @@ public class MvcCachedApplicationConfigurationClient : ICachedApplicationConfigu
             cacheKey = await CreateCacheKeyAsync();
             if (httpContext != null)
             {
-                httpContext.Items[ApplicationConfigurationDtoCacheKey] = cacheKey;
+                httpContext.Items[itemsKey] = cacheKey;
             }
         }
 
@@ -128,7 +129,8 @@ public class MvcCachedApplicationConfigurationClient : ICachedApplicationConfigu
     {
         string? cacheKey = null;
         var httpContext = HttpContextAccessor?.HttpContext;
-        if (httpContext != null && httpContext.Items[ApplicationConfigurationDtoCacheKey] is string key)
+        var itemsKey = GetHttpContextItemsCacheKey();
+        if (httpContext != null && httpContext.Items[itemsKey] is string key)
         {
             cacheKey = key;
         }
@@ -138,7 +140,7 @@ public class MvcCachedApplicationConfigurationClient : ICachedApplicationConfigu
             cacheKey = AsyncHelper.RunSync(CreateCacheKeyAsync);
             if (httpContext != null)
             {
-                httpContext.Items[ApplicationConfigurationDtoCacheKey] = cacheKey;
+                httpContext.Items[itemsKey] = cacheKey;
             }
         }
 
@@ -154,4 +156,9 @@ public class MvcCachedApplicationConfigurationClient : ICachedApplicationConfigu
     {
         return await CacheHelper.CreateCacheKeyAsync(CurrentUser.Id);
     }
+
+    protected virtual string GetHttpContextItemsCacheKey()
+    {
+        return string.Format(CultureInfo.InvariantCulture, HttpContextItemsCacheKeyFormat, CurrentUser.Id?.ToString("N") ?? "Anonymous", CultureInfo.CurrentUICulture.Name);
+    }
 }